Cargando…

Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease

Blood–brain barrier (BBB) dysfunction is emerging as a key pathogenic factor in the progression of Alzheimer’s disease (AD), where increased microvascular endothelial permeability has been proposed to play an important role. However, the molecular mechanisms leading to increased brain microvascular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jana, Arundhati, Wang, Xinge, Leasure, Joseph W., Magana, Lissette, Wang, Li, Kim, Young-Mee, Dodiya, Hemraj, Toth, Peter T., Sisodia, Sangram S., Rehman, Jalees
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526723/ https://www.ncbi.nlm.nih.gov/pubmed/36182964 http://dx.doi.org/10.1038/s41598-022-20889-y

Ejemplares similares

Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice
por: Dodiya, Hemraj B., et al.
Publicado: (2020)

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
por: Jambusaria, Ankit, et al.
Publicado: (2020)

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
por: Chandra, Sidhanth, et al.
Publicado: (2023)

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
por: Dodiya, Hemraj B., et al.
Publicado: (2019)

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
por: Chandra, Sidhanth, et al.
Publicado: (2023)

Systematic temporal analysis of peripheral blood transcriptomes using TrendCatcher identifies early and persistent neutrophil activation as a hallmark of severe COVID-19
por: Wang, Xinge, et al.
Publicado: (2021)

Temporal transcriptomic analysis using TrendCatcher identifies early and persistent neutrophil activation in severe COVID-19
por: Wang, Xinge, et al.
Publicado: (2022)

Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of β-catenin signaling
por: Kim, Young-Mee, et al.
Publicado: (2021)

Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism
por: Srivastava, Shubhi, et al.
Publicado: (2023)

Analysis of the interferon-γ-induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD
por: Naschberger, Elisabeth, et al.
Publicado: (2023)

Endothelial dysfunction and preeclampsia: role of oxidative stress
por: Sánchez-Aranguren, Lissette C., et al.
Publicado: (2014)

Donald Lowell Price, M.D. In memoriam
por: Sisodia, Sangram, et al.
Publicado: (2023)

Future of Probiotics and Prebiotics and the Implications for Early Career Researchers
por: Spacova, Irina, et al.
Publicado: (2020)

Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
por: Dodiya, Hemraj B., et al.
Publicado: (2021)

Biomarkers Assessing Endothelial Dysfunction in Alzheimer’s Disease
por: Custodia, Antía, et al.
Publicado: (2023)

The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain
por: Zhang, Xulun, et al.
Publicado: (2015)

Sox17 is required for endothelial regeneration following inflammation-induced vascular injury
por: Liu, Menglin, et al.
Publicado: (2019)

SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34(+) Progenitor Cells
por: Zhang, Lianghui, et al.
Publicado: (2017)

Measurement of endothelial dysfunction via peripheral arterial tonometry predicts vasculogenic erectile dysfunction
por: Kovac, Jason R., et al.
Publicado: (2014)

Endothelial Dysfunction in the Context of Blood–Brain Barrier Modeling
por: Kutikhin, A. G., et al.
Publicado: (2022)

Alteration in synaptic nanoscale organization dictates amyloidogenic processing in Alzheimer's disease
por: Kedia, Shekhar, et al.
Publicado: (2020)

Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells
por: Zhang, Yanmin, et al.
Publicado: (2013)

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease
por: Yamazaki, Yu, et al.
Publicado: (2017)

Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors
por: Veeraraghavalu, Karthikeyan, et al.
Publicado: (2013)

Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells
por: Wong, Pooi-Fong, et al.
Publicado: (2019)

Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
por: Kubra, Khadeja-Tul, et al.
Publicado: (2020)

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence
por: Kim, Young-Mee, et al.
Publicado: (2018)

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?
por: Montagne, Axel, et al.
Publicado: (2017)

Discerning the Role of Blood Brain Barrier Dysfunction in Alzheimer’s Disease
por: Tao, Qing-Qing, et al.
Publicado: (2022)

Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
por: Choi, Se Hoon, et al.
Publicado: (2009)

Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction
por: Zhang, Weijin, et al.
Publicado: (2017)

Site‐specific and endothelial‐mediated dysfunction of the alveolar‐capillary barrier in response to lipopolysaccharides
por: Janga, Harshavardhan, et al.
Publicado: (2017)

EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis
por: Tiruppathi, Chinnaswamy, et al.
Publicado: (2020)

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
por: Zhang, Liansheng, et al.
Publicado: (2021)

Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction
por: Batori, Robert K., et al.
Publicado: (2022)

Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
por: Wang, Dong, et al.
Publicado: (2021)

Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
por: Grammas, Paula
Publicado: (2011)

DRD1 downregulation contributes to mechanical stretch-induced lung endothelial barrier dysfunction
por: Wang, Yan, et al.
Publicado: (2021)

Endothelial Barrier Antigenimmunoreactivity is Conversely Associated with Blood-Brain Barrier Dysfunction after Embolic Stroke in Rats
por: Pelz, J., et al.
Publicado: (2013)

Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis
por: Ballesteros-Martinez, Constanza, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f9rs6cstkf0841op5tdtgqhnp0