Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

Antibodies with the same variable region can exist as multiple isotypes with varying neutralization potencies, though the mechanism for this is not fully defined. We previously isolated an HIV-directed IgA1 monoclonal antibody (mAb), CAP88-CH06, and showed that IgA1 and IgG3 isotypes of this antibod...

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Detalles Bibliográficos
Autores principales: Moyo-Gwete, Thandeka, Scheepers, Cathrine, Makhado, Zanele, Kgagudi, Prudence, Mzindle, Nonkululeko B., Ziki, Rutendo, Madzorera, Sharon, Manamela, Nelia P., Ayres, Frances, Lambson, Bronwen E., Richardson, Simone I., Morris, Lynn, Moore, Penny L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526727/
https://www.ncbi.nlm.nih.gov/pubmed/36182959
http://dx.doi.org/10.1038/s41598-022-20141-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526727/
https://www.ncbi.nlm.nih.gov/pubmed/36182959
http://dx.doi.org/10.1038/s41598-022-20141-7

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