Deubiquitylase OTUD1 confers Erlotinib sensitivity in non-small cell lung cancer through inhibition of nuclear translocation of YAP1

Evidence exists suggesting tumor-inhibiting properties of deubiquitylase OTUD1 in various malignancies. We herein investigated the anti-tumor effect and clarified the downstream mechanisms of OTUD1 in the chemoresistance of non-small cell lung cancer (NSCLC) cells. Expression of OTUD1 was examined i...

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Detalles Bibliográficos
Autores principales: Liu, Huafeng, Zhong, Liting, Lu, Yanjun, Liu, Xuewen, Wei, Jiawang, Ding, Yuhai, Huang, Huiling, Nie, Qihong, Liao, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526728/
https://www.ncbi.nlm.nih.gov/pubmed/36182943
http://dx.doi.org/10.1038/s41420-022-01119-w

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