The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022

Currently approved COVID vaccines are designed using the spike antigen derived from the ancestral strain, but health authorities are recommending changes to the vaccine strain to combat emerging variants. The goal is to ensure that next generation vaccines can tackle multiple variants of concern inc...

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Autores principales: Sridhar, Saranya, Chicz, Roman M., Warren, William, Tartaglia, Jim, Savarino, Stephen, Gurunathan, Sanjay, Toussaint, Jean-Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526810/
https://www.ncbi.nlm.nih.gov/pubmed/36184631
http://dx.doi.org/10.1038/s41467-022-33549-6
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author Sridhar, Saranya
Chicz, Roman M.
Warren, William
Tartaglia, Jim
Savarino, Stephen
Gurunathan, Sanjay
Toussaint, Jean-Francois
author_facet Sridhar, Saranya
Chicz, Roman M.
Warren, William
Tartaglia, Jim
Savarino, Stephen
Gurunathan, Sanjay
Toussaint, Jean-Francois
author_sort Sridhar, Saranya
collection PubMed
description Currently approved COVID vaccines are designed using the spike antigen derived from the ancestral strain, but health authorities are recommending changes to the vaccine strain to combat emerging variants. The goal is to ensure that next generation vaccines can tackle multiple variants of concern including the most prevalent variant for the coming season. We here discuss recent preclinical and clinical data on COVID vaccine antigens that are potential candidates for an updated vaccine.
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spelling pubmed-95268102022-10-03 The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022 Sridhar, Saranya Chicz, Roman M. Warren, William Tartaglia, Jim Savarino, Stephen Gurunathan, Sanjay Toussaint, Jean-Francois Nat Commun Comment Currently approved COVID vaccines are designed using the spike antigen derived from the ancestral strain, but health authorities are recommending changes to the vaccine strain to combat emerging variants. The goal is to ensure that next generation vaccines can tackle multiple variants of concern including the most prevalent variant for the coming season. We here discuss recent preclinical and clinical data on COVID vaccine antigens that are potential candidates for an updated vaccine. Nature Publishing Group UK 2022-10-02 /pmc/articles/PMC9526810/ /pubmed/36184631 http://dx.doi.org/10.1038/s41467-022-33549-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Sridhar, Saranya
Chicz, Roman M.
Warren, William
Tartaglia, Jim
Savarino, Stephen
Gurunathan, Sanjay
Toussaint, Jean-Francois
The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
title The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
title_full The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
title_fullStr The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
title_full_unstemmed The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
title_short The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022
title_sort potential of beta variant containing covid booster vaccines for chasing omicron in 2022
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526810/
https://www.ncbi.nlm.nih.gov/pubmed/36184631
http://dx.doi.org/10.1038/s41467-022-33549-6
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