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A dose-finding design for phase I clinical trials based on Bayesian stochastic approximation
BACKGROUND: Current dose-finding designs for phase I clinical trials can correctly select the MTD in a range of 30–80% depending on various conditions based on a sample of 30 subjects. However, there is still an unmet need for efficiency and cost saving. METHODS: We propose a novel dose-finding desi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526928/ https://www.ncbi.nlm.nih.gov/pubmed/36183071 http://dx.doi.org/10.1186/s12874-022-01741-3 |