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Descemet’s membrane folds in ochronosis: a case report
BACKGROUND: We present this report of a new ophthalmic finding in a patient with ochronosis. CASE PRESENTATION: An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscop...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526938/ https://www.ncbi.nlm.nih.gov/pubmed/36183119 http://dx.doi.org/10.1186/s13256-022-03599-x |
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author | de Azevedo Magalhaes, Otavio Abdel Rahman Abu Hwas, Dunia |
author_facet | de Azevedo Magalhaes, Otavio Abdel Rahman Abu Hwas, Dunia |
author_sort | de Azevedo Magalhaes, Otavio |
collection | PubMed |
description | BACKGROUND: We present this report of a new ophthalmic finding in a patient with ochronosis. CASE PRESENTATION: An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscopic examination, bilateral horizontal Descemet’s membrane folds were observed. Corneal tomography revealed irregular and asymmetric “against-the-rule” astigmatism in both eyes. Anterior segment optical coherence tomography demonstrated numerous central Descemet’s without edema or other corneal structure alterations. CONCLUSION: This is the first report of Descemet’s membrane folds in ochronosis. These corneal findings suggest that the accumulation of homogentisic acid in the sclera leads to thickening and stiffness of this region. These alterations could remarkably decrease visual acuity owing to topographic corneal curvature alterations, especially in elderly patients. |
format | Online Article Text |
id | pubmed-9526938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95269382022-10-03 Descemet’s membrane folds in ochronosis: a case report de Azevedo Magalhaes, Otavio Abdel Rahman Abu Hwas, Dunia J Med Case Rep Case Report BACKGROUND: We present this report of a new ophthalmic finding in a patient with ochronosis. CASE PRESENTATION: An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscopic examination, bilateral horizontal Descemet’s membrane folds were observed. Corneal tomography revealed irregular and asymmetric “against-the-rule” astigmatism in both eyes. Anterior segment optical coherence tomography demonstrated numerous central Descemet’s without edema or other corneal structure alterations. CONCLUSION: This is the first report of Descemet’s membrane folds in ochronosis. These corneal findings suggest that the accumulation of homogentisic acid in the sclera leads to thickening and stiffness of this region. These alterations could remarkably decrease visual acuity owing to topographic corneal curvature alterations, especially in elderly patients. BioMed Central 2022-10-02 /pmc/articles/PMC9526938/ /pubmed/36183119 http://dx.doi.org/10.1186/s13256-022-03599-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report de Azevedo Magalhaes, Otavio Abdel Rahman Abu Hwas, Dunia Descemet’s membrane folds in ochronosis: a case report |
title | Descemet’s membrane folds in ochronosis: a case report |
title_full | Descemet’s membrane folds in ochronosis: a case report |
title_fullStr | Descemet’s membrane folds in ochronosis: a case report |
title_full_unstemmed | Descemet’s membrane folds in ochronosis: a case report |
title_short | Descemet’s membrane folds in ochronosis: a case report |
title_sort | descemet’s membrane folds in ochronosis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526938/ https://www.ncbi.nlm.nih.gov/pubmed/36183119 http://dx.doi.org/10.1186/s13256-022-03599-x |
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