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Descemet’s membrane folds in ochronosis: a case report

BACKGROUND: We present this report of a new ophthalmic finding in a patient with ochronosis. CASE PRESENTATION: An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscop...

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Autores principales: de Azevedo Magalhaes, Otavio, Abdel Rahman Abu Hwas, Dunia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526938/
https://www.ncbi.nlm.nih.gov/pubmed/36183119
http://dx.doi.org/10.1186/s13256-022-03599-x
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author de Azevedo Magalhaes, Otavio
Abdel Rahman Abu Hwas, Dunia
author_facet de Azevedo Magalhaes, Otavio
Abdel Rahman Abu Hwas, Dunia
author_sort de Azevedo Magalhaes, Otavio
collection PubMed
description BACKGROUND: We present this report of a new ophthalmic finding in a patient with ochronosis. CASE PRESENTATION: An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscopic examination, bilateral horizontal Descemet’s membrane folds were observed. Corneal tomography revealed irregular and asymmetric “against-the-rule” astigmatism in both eyes. Anterior segment optical coherence tomography demonstrated numerous central Descemet’s without edema or other corneal structure alterations. CONCLUSION: This is the first report of Descemet’s membrane folds in ochronosis. These corneal findings suggest that the accumulation of homogentisic acid in the sclera leads to thickening and stiffness of this region. These alterations could remarkably decrease visual acuity owing to topographic corneal curvature alterations, especially in elderly patients.
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spelling pubmed-95269382022-10-03 Descemet’s membrane folds in ochronosis: a case report de Azevedo Magalhaes, Otavio Abdel Rahman Abu Hwas, Dunia J Med Case Rep Case Report BACKGROUND: We present this report of a new ophthalmic finding in a patient with ochronosis. CASE PRESENTATION: An 85-year-old Caucasian male patient with bilateral dark temporal and nasal pigmentation of conjunctiva and sclera was referred to our hospital owing to low visual acuity. On biomicroscopic examination, bilateral horizontal Descemet’s membrane folds were observed. Corneal tomography revealed irregular and asymmetric “against-the-rule” astigmatism in both eyes. Anterior segment optical coherence tomography demonstrated numerous central Descemet’s without edema or other corneal structure alterations. CONCLUSION: This is the first report of Descemet’s membrane folds in ochronosis. These corneal findings suggest that the accumulation of homogentisic acid in the sclera leads to thickening and stiffness of this region. These alterations could remarkably decrease visual acuity owing to topographic corneal curvature alterations, especially in elderly patients. BioMed Central 2022-10-02 /pmc/articles/PMC9526938/ /pubmed/36183119 http://dx.doi.org/10.1186/s13256-022-03599-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
de Azevedo Magalhaes, Otavio
Abdel Rahman Abu Hwas, Dunia
Descemet’s membrane folds in ochronosis: a case report
title Descemet’s membrane folds in ochronosis: a case report
title_full Descemet’s membrane folds in ochronosis: a case report
title_fullStr Descemet’s membrane folds in ochronosis: a case report
title_full_unstemmed Descemet’s membrane folds in ochronosis: a case report
title_short Descemet’s membrane folds in ochronosis: a case report
title_sort descemet’s membrane folds in ochronosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526938/
https://www.ncbi.nlm.nih.gov/pubmed/36183119
http://dx.doi.org/10.1186/s13256-022-03599-x
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