β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

BACKGROUND: Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatisfactory and shows intractable side effects. Multiple evidence suggests that dop...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Song, Nanshan, Yao, Hang, Jiang, Siyuan, Wang, Yueping, Zheng, Ying, Zhou, Yuanzhang, Ding, Jianhua, Hu, Gang, Lu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526944/
https://www.ncbi.nlm.nih.gov/pubmed/36183107
http://dx.doi.org/10.1186/s12974-022-02597-6

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