Cargando…
Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy
Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue na...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526989/ https://www.ncbi.nlm.nih.gov/pubmed/36182921 http://dx.doi.org/10.1186/s12951-022-01633-0 |
_version_ | 1784800990236508160 |
---|---|
author | Yang, Linjun Yu, Congcong Fan, Xuhui Zeng, Tianni Yang, Wentao Xia, Jiechao Wang, Jianle Yao, Litao Hu, Chuan Jin, Yang Zhu, Yutao Chen, Jiaxin Hu, Zhijun |
author_facet | Yang, Linjun Yu, Congcong Fan, Xuhui Zeng, Tianni Yang, Wentao Xia, Jiechao Wang, Jianle Yao, Litao Hu, Chuan Jin, Yang Zhu, Yutao Chen, Jiaxin Hu, Zhijun |
author_sort | Yang, Linjun |
collection | PubMed |
description | Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) with promising antibacterial, antioxidation, rapid gelation, and self-healing characteristics was designed via dual-dynamic-bond cross-linking among the oxidized hyaluronic acid (OHA), borax, and gelatin. The mechanical performance of the hydrogel was studied by dynamic mechanical analysis. Meanwhile, the swelling ratio and degradation level of the hydrogel was explored. Benefiting from its remarkable mechanical properties, sufficient tissue adhesiveness, and ideal shape-adaptability, the injectable PBNPs containing hydrogel was explored for IVDD therapy. Astoundingly, the as-fabricated hydrogel was able to alleviate H(2)O(2)-induced excessive ROS against oxidative stress trauma of nucleus pulposus, which was further revealed by theoretical calculations. Rat IVDD model was next established to estimate therapeutic effect of this PBNPs@OBG hydrogel for IVDD treatment in vivo. On the whole, combination of the smart multifunctional hydrogel and nanotechnology-mediated antioxidant therapy can serve as a fire-new general type of therapeutic strategy for IVDD and other oxidative stress-related diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01633-0. |
format | Online Article Text |
id | pubmed-9526989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95269892022-10-03 Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy Yang, Linjun Yu, Congcong Fan, Xuhui Zeng, Tianni Yang, Wentao Xia, Jiechao Wang, Jianle Yao, Litao Hu, Chuan Jin, Yang Zhu, Yutao Chen, Jiaxin Hu, Zhijun J Nanobiotechnology Research Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) with promising antibacterial, antioxidation, rapid gelation, and self-healing characteristics was designed via dual-dynamic-bond cross-linking among the oxidized hyaluronic acid (OHA), borax, and gelatin. The mechanical performance of the hydrogel was studied by dynamic mechanical analysis. Meanwhile, the swelling ratio and degradation level of the hydrogel was explored. Benefiting from its remarkable mechanical properties, sufficient tissue adhesiveness, and ideal shape-adaptability, the injectable PBNPs containing hydrogel was explored for IVDD therapy. Astoundingly, the as-fabricated hydrogel was able to alleviate H(2)O(2)-induced excessive ROS against oxidative stress trauma of nucleus pulposus, which was further revealed by theoretical calculations. Rat IVDD model was next established to estimate therapeutic effect of this PBNPs@OBG hydrogel for IVDD treatment in vivo. On the whole, combination of the smart multifunctional hydrogel and nanotechnology-mediated antioxidant therapy can serve as a fire-new general type of therapeutic strategy for IVDD and other oxidative stress-related diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01633-0. BioMed Central 2022-10-01 /pmc/articles/PMC9526989/ /pubmed/36182921 http://dx.doi.org/10.1186/s12951-022-01633-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yang, Linjun Yu, Congcong Fan, Xuhui Zeng, Tianni Yang, Wentao Xia, Jiechao Wang, Jianle Yao, Litao Hu, Chuan Jin, Yang Zhu, Yutao Chen, Jiaxin Hu, Zhijun Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
title | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
title_full | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
title_fullStr | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
title_full_unstemmed | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
title_short | Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
title_sort | dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526989/ https://www.ncbi.nlm.nih.gov/pubmed/36182921 http://dx.doi.org/10.1186/s12951-022-01633-0 |
work_keys_str_mv | AT yanglinjun dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT yucongcong dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT fanxuhui dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT zengtianni dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT yangwentao dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT xiajiechao dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT wangjianle dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT yaolitao dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT huchuan dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT jinyang dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT zhuyutao dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT chenjiaxin dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy AT huzhijun dualdynamicbondcrosslinkedinjectablehydrogelofmultifunctionforintervertebraldiscdegenerationtherapy |