The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury

Spinal cord injury (SCI) triggers neuroinflammation, and subsequently secondary degeneration and oligodendrocyte (OL) death. We report that the alarmin interleukin (IL)−1α is produced by damaged microglia after SCI. Intra-cisterna magna injection of IL-1α in mice rapidly induces neutrophil infiltrat...

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Detalles Bibliográficos
Autores principales: Bretheau, Floriane, Castellanos-Molina, Adrian, Bélanger, Dominic, Kusik, Maxime, Mailhot, Benoit, Boisvert, Ana, Vallières, Nicolas, Lessard, Martine, Gunzer, Matthias, Liu, Xiaoyu, Boilard, Éric, Quan, Ning, Lacroix, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527244/
https://www.ncbi.nlm.nih.gov/pubmed/36184639
http://dx.doi.org/10.1038/s41467-022-33463-x

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