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Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity

As a traditional Chinese herbal medicine, Panax ginseng C. A. Meyer (PG) has preventive and therapeutic effects on various diseases. Ginsenosides are main active ingredients of PG and have good pharmacological effects. Due to the diversity of chemical structures and physicochemical properties of gin...

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Autores principales: Wang, Xinyi, Wang, Rongcan, Qiao, Yongfei, Li, Yali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527293/
https://www.ncbi.nlm.nih.gov/pubmed/36199681
http://dx.doi.org/10.3389/fphar.2022.1022266
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author Wang, Xinyi
Wang, Rongcan
Qiao, Yongfei
Li, Yali
author_facet Wang, Xinyi
Wang, Rongcan
Qiao, Yongfei
Li, Yali
author_sort Wang, Xinyi
collection PubMed
description As a traditional Chinese herbal medicine, Panax ginseng C. A. Meyer (PG) has preventive and therapeutic effects on various diseases. Ginsenosides are main active ingredients of PG and have good pharmacological effects. Due to the diversity of chemical structures and physicochemical properties of ginsenosides, Currently, related studies on PG monomer saponins are mainly focused on the cardiovascular system, nervous system, antidiabetic, and antitumor. There are few types of research on the toxin treatment, predominantly exogenous toxicity. PG and its monomer ginsenosides are undoubtedly a practical option for treating exogenous toxicity for drug-induced or metal-induced side effects such as nephrotoxicity, hepatotoxicity, cardiotoxicity, metal toxicity and other exogenous toxicity caused by drugs or metals. The mechanism focuses on antioxidant, anti-inflammatory, and anti-apoptotic, as well as modulation of signaling pathways. It summarized the therapeutic effects of ginseng monomer saponins on exogenous toxicity and demonstrated that ginsenosides could be used as potential drugs to treat exogenous toxicity and reduce drug toxicities.
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spelling pubmed-95272932022-10-04 Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity Wang, Xinyi Wang, Rongcan Qiao, Yongfei Li, Yali Front Pharmacol Pharmacology As a traditional Chinese herbal medicine, Panax ginseng C. A. Meyer (PG) has preventive and therapeutic effects on various diseases. Ginsenosides are main active ingredients of PG and have good pharmacological effects. Due to the diversity of chemical structures and physicochemical properties of ginsenosides, Currently, related studies on PG monomer saponins are mainly focused on the cardiovascular system, nervous system, antidiabetic, and antitumor. There are few types of research on the toxin treatment, predominantly exogenous toxicity. PG and its monomer ginsenosides are undoubtedly a practical option for treating exogenous toxicity for drug-induced or metal-induced side effects such as nephrotoxicity, hepatotoxicity, cardiotoxicity, metal toxicity and other exogenous toxicity caused by drugs or metals. The mechanism focuses on antioxidant, anti-inflammatory, and anti-apoptotic, as well as modulation of signaling pathways. It summarized the therapeutic effects of ginseng monomer saponins on exogenous toxicity and demonstrated that ginsenosides could be used as potential drugs to treat exogenous toxicity and reduce drug toxicities. Frontiers Media S.A. 2022-09-19 /pmc/articles/PMC9527293/ /pubmed/36199681 http://dx.doi.org/10.3389/fphar.2022.1022266 Text en Copyright © 2022 Wang, Wang, Qiao and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wang, Xinyi
Wang, Rongcan
Qiao, Yongfei
Li, Yali
Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
title Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
title_full Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
title_fullStr Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
title_full_unstemmed Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
title_short Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
title_sort progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527293/
https://www.ncbi.nlm.nih.gov/pubmed/36199681
http://dx.doi.org/10.3389/fphar.2022.1022266
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