Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin

The present study focused on the development of Cur-loaded SOHA nanogels (Cur-SHNGs) to enhance the topical administration of Cur. The physiochemical properties of Cur-SHNGs were characterized. Results showed that the morphology of the Cur-SHNGs was spherical, the average size was 171.37 nm with a z...

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Autores principales: Niu, Jiangxiu, Yuan, Ming, Liu, Yao, Wang, Liye, Tang, Zigui, Wang, Yihan, Qi, Yueheng, Zhang, Yansong, Ya, Huiyuan, Fan, Yanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527322/
https://www.ncbi.nlm.nih.gov/pubmed/36199664
http://dx.doi.org/10.3389/fchem.2022.1028372
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author Niu, Jiangxiu
Yuan, Ming
Liu, Yao
Wang, Liye
Tang, Zigui
Wang, Yihan
Qi, Yueheng
Zhang, Yansong
Ya, Huiyuan
Fan, Yanli
author_facet Niu, Jiangxiu
Yuan, Ming
Liu, Yao
Wang, Liye
Tang, Zigui
Wang, Yihan
Qi, Yueheng
Zhang, Yansong
Ya, Huiyuan
Fan, Yanli
author_sort Niu, Jiangxiu
collection PubMed
description The present study focused on the development of Cur-loaded SOHA nanogels (Cur-SHNGs) to enhance the topical administration of Cur. The physiochemical properties of Cur-SHNGs were characterized. Results showed that the morphology of the Cur-SHNGs was spherical, the average size was 171.37 nm with a zeta potential of −13.23 mV. Skin permeation experiments were carried out using the diffusion cell systems. It was found that the skin retention of Cur-SHNGs was significantly improved since it showed the best retention value (0.66 ± 0.17 μg/cm(2)). In addition, the hematoxylin and eosin staining showed that the Cur-SHNGs improved transdermal drug delivery by altering the skin microstructure. Fluorescence imaging indicated that Cur-SHNGs could effectively deliver the drug to the deeper layers of the skin. Additionally, Cur-SHNGs showed significant analgesic and anti-inflammatory activity with no skin irritation. Taken together, Cur-SHNGs could be effectively used for the topical delivery of therapeutic drugs.
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spelling pubmed-95273222022-10-04 Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin Niu, Jiangxiu Yuan, Ming Liu, Yao Wang, Liye Tang, Zigui Wang, Yihan Qi, Yueheng Zhang, Yansong Ya, Huiyuan Fan, Yanli Front Chem Chemistry The present study focused on the development of Cur-loaded SOHA nanogels (Cur-SHNGs) to enhance the topical administration of Cur. The physiochemical properties of Cur-SHNGs were characterized. Results showed that the morphology of the Cur-SHNGs was spherical, the average size was 171.37 nm with a zeta potential of −13.23 mV. Skin permeation experiments were carried out using the diffusion cell systems. It was found that the skin retention of Cur-SHNGs was significantly improved since it showed the best retention value (0.66 ± 0.17 μg/cm(2)). In addition, the hematoxylin and eosin staining showed that the Cur-SHNGs improved transdermal drug delivery by altering the skin microstructure. Fluorescence imaging indicated that Cur-SHNGs could effectively deliver the drug to the deeper layers of the skin. Additionally, Cur-SHNGs showed significant analgesic and anti-inflammatory activity with no skin irritation. Taken together, Cur-SHNGs could be effectively used for the topical delivery of therapeutic drugs. Frontiers Media S.A. 2022-09-19 /pmc/articles/PMC9527322/ /pubmed/36199664 http://dx.doi.org/10.3389/fchem.2022.1028372 Text en Copyright © 2022 Niu, Yuan, Liu, Wang, Tang, Wang, Qi, Zhang, Ya and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Niu, Jiangxiu
Yuan, Ming
Liu, Yao
Wang, Liye
Tang, Zigui
Wang, Yihan
Qi, Yueheng
Zhang, Yansong
Ya, Huiyuan
Fan, Yanli
Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
title Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
title_full Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
title_fullStr Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
title_full_unstemmed Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
title_short Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
title_sort silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527322/
https://www.ncbi.nlm.nih.gov/pubmed/36199664
http://dx.doi.org/10.3389/fchem.2022.1028372
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