The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses

12/15-lipoxygenase (12/15-LOX) is a member of the lipoxygenase family, which can catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites, such as 12-hydroxyeicosatetraenoic acid (12-HETE), 15-HETE, lipoxin (LX), hepoxilin, resolvin, protectin, and maresins. 12/15-LO...

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Detalles Bibliográficos
Autores principales: Tan, Ruyu, Yan, Bing, Wang, Chengshuo, Zhang, Luo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527411/
https://www.ncbi.nlm.nih.gov/pubmed/36199753
http://dx.doi.org/10.1155/2022/4589191
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author Tan, Ruyu
Yan, Bing
Wang, Chengshuo
Zhang, Luo
author_facet Tan, Ruyu
Yan, Bing
Wang, Chengshuo
Zhang, Luo
author_sort Tan, Ruyu
collection PubMed
description 12/15-lipoxygenase (12/15-LOX) is a member of the lipoxygenase family, which can catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites, such as 12-hydroxyeicosatetraenoic acid (12-HETE), 15-HETE, lipoxin (LX), hepoxilin, resolvin, protectin, and maresins. 12/15-LOX and its metabolites take part in inflammatory responses and mediate related signalling pathways, playing an essential role in various inflammatory diseases. So the definition, catalytic substrates, metabolites of 12/15-lipoxygenase, and their roles in inflammatory responses are reviewed in this article.
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spelling pubmed-95274112022-10-04 The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses Tan, Ruyu Yan, Bing Wang, Chengshuo Zhang, Luo Biomed Res Int Research Article 12/15-lipoxygenase (12/15-LOX) is a member of the lipoxygenase family, which can catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites, such as 12-hydroxyeicosatetraenoic acid (12-HETE), 15-HETE, lipoxin (LX), hepoxilin, resolvin, protectin, and maresins. 12/15-LOX and its metabolites take part in inflammatory responses and mediate related signalling pathways, playing an essential role in various inflammatory diseases. So the definition, catalytic substrates, metabolites of 12/15-lipoxygenase, and their roles in inflammatory responses are reviewed in this article. Hindawi 2022-09-25 /pmc/articles/PMC9527411/ /pubmed/36199753 http://dx.doi.org/10.1155/2022/4589191 Text en Copyright © 2022 Ruyu Tan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tan, Ruyu
Yan, Bing
Wang, Chengshuo
Zhang, Luo
The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
title The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
title_full The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
title_fullStr The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
title_full_unstemmed The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
title_short The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses
title_sort role of 12/15-lipoxygenase and its various metabolites generated from multiple polyunsaturated fatty acids as substrates in inflammatory responses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527411/
https://www.ncbi.nlm.nih.gov/pubmed/36199753
http://dx.doi.org/10.1155/2022/4589191
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