EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma

BACKGROUND: Epidermal growth factor receptor (EGFR) amplification and TP53 mutation are the two most common genetic alterations in glioblastoma multiforme (GBM). A comprehensive analysis of the TCGA GBM database revealed a subgroup with near mutual exclusivity of EGFR amplification and TP53 mutation...

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Detalles Bibliográficos
Autores principales: Ding, Jie, Li, Xiaolong, Khan, Sabbir, Zhang, Chen, Gao, Feng, Sen, Shayak, Wasylishen, Amanda R, Zhao, Yang, Lozano, Guillermina, Koul, Dimpy, Alfred Yung, W K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527520/
https://www.ncbi.nlm.nih.gov/pubmed/35474131
http://dx.doi.org/10.1093/neuonc/noac105

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