STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma

BACKGROUND: H3K27M-mutant diffuse midline glioma (DMG) is a lethal brain tumor that usually occurs in children. Despite advances in our understanding of its underlying biology, efficacious therapies are severely lacking. METHODS: We screened a library of drugs either FDA-approved or in clinical tria...

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Detalles Bibliográficos
Autores principales: Zhang, Liang, Nesvick, Cody L, Day, Charlie A, Choi, Jonghoon, Lu, Victor M, Peterson, Timothy, Power, Erica A, Anderson, Jacob B, Hamdan, Feda H, Decker, Paul A, Simons, Renae, Welby, John P, Siada, Ruby, Ge, Jizhi, Kaptzan, Tatiana, Johnsen, Steven A, Hinchcliffe, Edward H, Daniels, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527528/
https://www.ncbi.nlm.nih.gov/pubmed/35397475
http://dx.doi.org/10.1093/neuonc/noac093

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