Cargando…

New regulators of the tetracycline‐inducible gene expression system identified by chemical and genetic screens

The tetracycline repressor (tetR)‐regulated system is a widely used tool to specifically control gene expression in mammalian cells. Based on this system, we generated a human osteosarcoma cell line, which allows for the inducible expression of an EGFP fusion of the TAR DNA‐binding protein 43 (TDP‐4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Colicchia, Valeria, Häggblad, Maria, Sirozh, Oleksandra, Porebski, Bartlomiej, Balan, Mirela, Li, Xuexin, Lidemalm, Louise, Carreras‐Puigvert, Jordi, Hühn, Daniela, Fernandez‐Capetillo, Oscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527584/ https://www.ncbi.nlm.nih.gov/pubmed/36062323 http://dx.doi.org/10.1002/2211-5463.13482

Ejemplares similares

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells
por: Hühn, Daniela, et al.
Publicado: (2021)

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors
por: Corman, Alba, et al.
Publicado: (2021)

A chemical screen underscores the essential role of STAT1-dependent IFNγ signaling to regulate HLA-I expression in cancer cells
por: Barz, Myriam, et al.
Publicado: (2023)

High content drug screening for Fanconi anemia therapeutics
por: Montanuy, Helena, et al.
Publicado: (2020)

Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection
por: Seal, Srijit, et al.
Publicado: (2022)

Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells
por: Sanchez‐Burgos, Laura, et al.
Publicado: (2022)

Merging bioactivity predictions from cell morphology and chemical fingerprint models using similarity to training data
por: Seal, Srijit, et al.
Publicado: (2023)

Pleiotropy of chemically modified tetracycline in periodontitis
por: Agarwal, Ashish
Publicado: (2013)

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity
por: Espinoza, Jaime A., et al.
Publicado: (2019)

PopulationProfiler: A Tool for Population Analysis and Visualization of Image-Based Cell Screening Data
por: Matuszewski, Damian J., et al.
Publicado: (2016)

Chemically modified tetracyclines: The novel host modulating agents
por: Swamy, Devulapalli Narasimha, et al.
Publicado: (2015)

A Multiparametric and High-Throughput Platform for Host–Virus Binding Screens
por: Schlegel, Jan, et al.
Publicado: (2023)

Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs
por: Fuoco, Domenico
Publicado: (2012)

Chemical Pleurodesis Using Tetracycline for the Management of Postoperative Pneumothorax Recurrence
por: Yang, Jun Tae, et al.
Publicado: (2023)

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells
por: Olbrich, Teresa, et al.
Publicado: (2019)

Chemically modified tetracyclines: Novel therapeutic agents in the management of chronic periodontitis
por: Agnihotri, Rupali, et al.
Publicado: (2012)

Combinatorial Computational Approaches to Identify Tetracycline Derivatives as Flavivirus Inhibitors
por: Yang, Jinn-Moon, et al.
Publicado: (2007)

Tetracyclines in malaria
por: Gaillard, Tiphaine, et al.
Publicado: (2015)

Tetracycline Allergy
por: Hamilton, Leslie A., et al.
Publicado: (2019)

Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
por: Borshchev, Yury Yu, et al.
Publicado: (2019)

Investigation of Changes in Tetracycline Repressor Binding upon Mutations in the Tetracycline Operator
por: Bolintineanu, Dan S., et al.
Publicado: (2014)

Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control
por: Baumschlager, Armin, et al.
Publicado: (2020)

Tetracyclines and Neuromuscular Disorders
por: Orsucci, Daniele, et al.
Publicado: (2012)

Honeybees and Tetracycline Resistance
por: Levy, Stuart B., et al.
Publicado: (2013)

Tetracycline-Inactivating Enzymes
por: Markley, Jana L., et al.
Publicado: (2018)

Assessment of Tetracyclines Residues and Tetracycline Resistant Bacteria in Conventional and Organic Baby Foods
por: Guarddon, Mónica, et al.
Publicado: (2015)

“Tetracycline hydrochloride chemical burn” as self-inflicted mucogingival injury: A rare case report
por: Dayakar, Mundoor Manjunath, et al.
Publicado: (2012)

Tetracycline Resistance Genes Identified from Distinct Soil Environments in China by Functional Metagenomics
por: Wang, Shaochen, et al.
Publicado: (2017)

NOX4 regulates TGFβ‐induced proliferation and self‐renewal in glioblastoma stem cells
por: García‐Gómez, Pedro, et al.
Publicado: (2022)

Streptomycin and the Tetracyclines in Acute Appendicitis
por: Dales, H. C.
Publicado: (1954)

Tetracycline fluorescence in experimental tumours.
por: Tapp, E., et al.
Publicado: (1965)

Stochastic simulations of the tetracycline operon
por: Biliouris, Konstantinos, et al.
Publicado: (2011)

Omadacycline: A Modernized Tetracycline
por: Gallagher, Jason C
Publicado: (2019)

A phenomics approach for antiviral drug discovery
por: Rietdijk, Jonne, et al.
Publicado: (2021)

Evaluating the utility of brightfield image data for mechanism of action prediction
por: Harrison, Philip John, et al.
Publicado: (2023)

COL-3, a Chemically Modified Tetracycline, Inhibits Lipopolysaccharide-Induced Microglia Activation and Cytokine Expression in the Brain
por: Edan, Rawan Abdulhameed, et al.
Publicado: (2013)

CMT-308, a Nonantimicrobial Chemically-Modified Tetracycline, Exhibits Anti-Melanogenic Activity by Suppression of Melanosome Export
por: Goenka, Shilpi, et al.
Publicado: (2020)

THE CLINICAL APPLICATION OF ANTIBIOTICS—CHLORAMPHENICOL AND THE TETRACYCLINES
Publicado: (1957)

Tetracyclines and mineralized tissues: review and perspectives.
por: Skinner, H. C., et al.
Publicado: (1975)

Tetracycline-inducible gene regulation in mycobacteria
por: Blokpoel, Marian C. J., et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_vbkpktl4og0ibc397bbpem35be