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NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently administered drugs, mainly for their anti-pyretic, but also for pain-relieving and anti-inflammatory effects in children. NSAIDs are composed of structurally divergent subgroups of drugs with similar pharmacological and adv...

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Autores principales: Cavkaytar, Ozlem, Arga, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527698/
https://www.ncbi.nlm.nih.gov/pubmed/36199560
http://dx.doi.org/10.2147/JAA.S267005
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author Cavkaytar, Ozlem
Arga, Mustafa
author_facet Cavkaytar, Ozlem
Arga, Mustafa
author_sort Cavkaytar, Ozlem
collection PubMed
description Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently administered drugs, mainly for their anti-pyretic, but also for pain-relieving and anti-inflammatory effects in children. NSAIDs are composed of structurally divergent subgroups of drugs with similar pharmacological and adverse effects. Aspirin originates from salicin and was the first synthesized analgesic. As a prototype of NSAIDs; aspirin-induced hypersensitivity reactions were first reported, but subsequently, other phenotypes of hypersensitivity reactions were also described with aspirin and other NSAIDs. There are certain challenging aspects of NSAID-hypersensitivity in the pediatric population that need to be further investigated. These include the effect of age on drug metabolism and the natural history of the various phenotypes of NSAID-hypersensitivity, the effect of certain co-factors (infections, exercise) on NSAID-hypersensitivity, and diagnostic clinical and laboratory biomarkers clarifying the endotypes. In recent years, a non-negligible number of case series, studies and expert panel reports have been published in this field with some novel features and diagnostic modalities in the pediatric population. With the current review; the clinical phenotypes and diagnostic and management modalities of suspected NSAID-induced hypersensitivity reactions in childhood and adolescence were explained and updated by examining past and current publications.
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spelling pubmed-95276982022-10-04 NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies Cavkaytar, Ozlem Arga, Mustafa J Asthma Allergy Review Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently administered drugs, mainly for their anti-pyretic, but also for pain-relieving and anti-inflammatory effects in children. NSAIDs are composed of structurally divergent subgroups of drugs with similar pharmacological and adverse effects. Aspirin originates from salicin and was the first synthesized analgesic. As a prototype of NSAIDs; aspirin-induced hypersensitivity reactions were first reported, but subsequently, other phenotypes of hypersensitivity reactions were also described with aspirin and other NSAIDs. There are certain challenging aspects of NSAID-hypersensitivity in the pediatric population that need to be further investigated. These include the effect of age on drug metabolism and the natural history of the various phenotypes of NSAID-hypersensitivity, the effect of certain co-factors (infections, exercise) on NSAID-hypersensitivity, and diagnostic clinical and laboratory biomarkers clarifying the endotypes. In recent years, a non-negligible number of case series, studies and expert panel reports have been published in this field with some novel features and diagnostic modalities in the pediatric population. With the current review; the clinical phenotypes and diagnostic and management modalities of suspected NSAID-induced hypersensitivity reactions in childhood and adolescence were explained and updated by examining past and current publications. Dove 2022-09-28 /pmc/articles/PMC9527698/ /pubmed/36199560 http://dx.doi.org/10.2147/JAA.S267005 Text en © 2022 Cavkaytar and Arga. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Cavkaytar, Ozlem
Arga, Mustafa
NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies
title NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies
title_full NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies
title_fullStr NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies
title_full_unstemmed NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies
title_short NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies
title_sort nsaid hypersensitivity in the pediatric population: classification and diagnostic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527698/
https://www.ncbi.nlm.nih.gov/pubmed/36199560
http://dx.doi.org/10.2147/JAA.S267005
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