Cargando…
Local immune recognition of trophoblast in early human pregnancy: controversies and questions
The role of the maternal immune system in reproductive success in humans remains controversial. Here we focus on the events that occur in the maternal decidua during the first few weeks of human pregnancy, because this is the site at which maternal leukocytes initially interact with and can recogniz...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527719/ https://www.ncbi.nlm.nih.gov/pubmed/36192648 http://dx.doi.org/10.1038/s41577-022-00777-2 |
_version_ | 1784801134469185536 |
---|---|
author | Moffett, Ashley Shreeve, Norman |
author_facet | Moffett, Ashley Shreeve, Norman |
author_sort | Moffett, Ashley |
collection | PubMed |
description | The role of the maternal immune system in reproductive success in humans remains controversial. Here we focus on the events that occur in the maternal decidua during the first few weeks of human pregnancy, because this is the site at which maternal leukocytes initially interact with and can recognize fetal trophoblast cells, potentially involving allorecognition by both T cells and natural killer (NK) cells. NK cells are the dominant leukocyte population in first-trimester decidua, and genetic studies point to a role of allorecognition by uterine NK cells in establishing a boundary between the mother and the fetus. By contrast, definitive evidence that allorecognition by decidual T cells occurs during the first trimester is lacking. Thus, our view is that during the crucial period when the placenta is established, damaging T cell-mediated adaptive immune responses towards placental trophoblast are minimized, whereas NK cell allorecognition contributes to successful implantation and healthy pregnancy. |
format | Online Article Text |
id | pubmed-9527719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95277192022-10-03 Local immune recognition of trophoblast in early human pregnancy: controversies and questions Moffett, Ashley Shreeve, Norman Nat Rev Immunol Review Article The role of the maternal immune system in reproductive success in humans remains controversial. Here we focus on the events that occur in the maternal decidua during the first few weeks of human pregnancy, because this is the site at which maternal leukocytes initially interact with and can recognize fetal trophoblast cells, potentially involving allorecognition by both T cells and natural killer (NK) cells. NK cells are the dominant leukocyte population in first-trimester decidua, and genetic studies point to a role of allorecognition by uterine NK cells in establishing a boundary between the mother and the fetus. By contrast, definitive evidence that allorecognition by decidual T cells occurs during the first trimester is lacking. Thus, our view is that during the crucial period when the placenta is established, damaging T cell-mediated adaptive immune responses towards placental trophoblast are minimized, whereas NK cell allorecognition contributes to successful implantation and healthy pregnancy. Nature Publishing Group UK 2022-10-03 2023 /pmc/articles/PMC9527719/ /pubmed/36192648 http://dx.doi.org/10.1038/s41577-022-00777-2 Text en © Springer Nature Limited 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Moffett, Ashley Shreeve, Norman Local immune recognition of trophoblast in early human pregnancy: controversies and questions |
title | Local immune recognition of trophoblast in early human pregnancy: controversies and questions |
title_full | Local immune recognition of trophoblast in early human pregnancy: controversies and questions |
title_fullStr | Local immune recognition of trophoblast in early human pregnancy: controversies and questions |
title_full_unstemmed | Local immune recognition of trophoblast in early human pregnancy: controversies and questions |
title_short | Local immune recognition of trophoblast in early human pregnancy: controversies and questions |
title_sort | local immune recognition of trophoblast in early human pregnancy: controversies and questions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527719/ https://www.ncbi.nlm.nih.gov/pubmed/36192648 http://dx.doi.org/10.1038/s41577-022-00777-2 |
work_keys_str_mv | AT moffettashley localimmunerecognitionoftrophoblastinearlyhumanpregnancycontroversiesandquestions AT shreevenorman localimmunerecognitionoftrophoblastinearlyhumanpregnancycontroversiesandquestions |