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Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527740/ https://www.ncbi.nlm.nih.gov/pubmed/36190645 http://dx.doi.org/10.1007/s12064-022-00379-5 |
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author | Elbaz, I. M. Sohaly, M. A. El-Metwally, H. |
author_facet | Elbaz, I. M. Sohaly, M. A. El-Metwally, H. |
author_sort | Elbaz, I. M. |
collection | PubMed |
description | In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established. Our study shows the extinction and persistence of the disease inside the human body through the stability analysis of the disease-free equilibrium [Formula: see text] and the endemic equilibrium [Formula: see text] , respectively. Moreover, we show the impact of delay tactics and noise on the extinction of the disease. The most interesting result is even if the deterministic system is inevitably pandemic at a specific point, extinction will become possible in the stochastic version of our model. |
format | Online Article Text |
id | pubmed-9527740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-95277402022-10-03 Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay Elbaz, I. M. Sohaly, M. A. El-Metwally, H. Theory Biosci Original Article In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established. Our study shows the extinction and persistence of the disease inside the human body through the stability analysis of the disease-free equilibrium [Formula: see text] and the endemic equilibrium [Formula: see text] , respectively. Moreover, we show the impact of delay tactics and noise on the extinction of the disease. The most interesting result is even if the deterministic system is inevitably pandemic at a specific point, extinction will become possible in the stochastic version of our model. Springer Berlin Heidelberg 2022-10-03 2022 /pmc/articles/PMC9527740/ /pubmed/36190645 http://dx.doi.org/10.1007/s12064-022-00379-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Elbaz, I. M. Sohaly, M. A. El-Metwally, H. Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay |
title | Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay |
title_full | Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay |
title_fullStr | Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay |
title_full_unstemmed | Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay |
title_short | Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay |
title_sort | modeling the stochastic within-host dynamics sars-cov-2 infection with discrete delay |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527740/ https://www.ncbi.nlm.nih.gov/pubmed/36190645 http://dx.doi.org/10.1007/s12064-022-00379-5 |
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