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Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay

In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established...

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Autores principales: Elbaz, I. M., Sohaly, M. A., El-Metwally, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527740/
https://www.ncbi.nlm.nih.gov/pubmed/36190645
http://dx.doi.org/10.1007/s12064-022-00379-5
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author Elbaz, I. M.
Sohaly, M. A.
El-Metwally, H.
author_facet Elbaz, I. M.
Sohaly, M. A.
El-Metwally, H.
author_sort Elbaz, I. M.
collection PubMed
description In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established. Our study shows the extinction and persistence of the disease inside the human body through the stability analysis of the disease-free equilibrium [Formula: see text] and the endemic equilibrium [Formula: see text] , respectively. Moreover, we show the impact of delay tactics and noise on the extinction of the disease. The most interesting result is even if the deterministic system is inevitably pandemic at a specific point, extinction will become possible in the stochastic version of our model.
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spelling pubmed-95277402022-10-03 Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay Elbaz, I. M. Sohaly, M. A. El-Metwally, H. Theory Biosci Original Article In this paper, a new mathematical model that describes the dynamics of the within-host COVID-19 epidemic is formulated. We show the stochastic dynamics of Target-Latent-Infected-Virus free within the human body with discrete delay and noise. Positivity and uniqueness of the solutions are established. Our study shows the extinction and persistence of the disease inside the human body through the stability analysis of the disease-free equilibrium [Formula: see text] and the endemic equilibrium [Formula: see text] , respectively. Moreover, we show the impact of delay tactics and noise on the extinction of the disease. The most interesting result is even if the deterministic system is inevitably pandemic at a specific point, extinction will become possible in the stochastic version of our model. Springer Berlin Heidelberg 2022-10-03 2022 /pmc/articles/PMC9527740/ /pubmed/36190645 http://dx.doi.org/10.1007/s12064-022-00379-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Elbaz, I. M.
Sohaly, M. A.
El-Metwally, H.
Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
title Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
title_full Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
title_fullStr Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
title_full_unstemmed Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
title_short Modeling the stochastic within-host dynamics SARS-CoV-2 infection with discrete delay
title_sort modeling the stochastic within-host dynamics sars-cov-2 infection with discrete delay
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527740/
https://www.ncbi.nlm.nih.gov/pubmed/36190645
http://dx.doi.org/10.1007/s12064-022-00379-5
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