Barriers to the Intestinal Absorption of Four Insulin-Loaded Arginine-Rich Nanoparticles in Human and Rat

[Image: see text] Peptide drugs and biologics provide opportunities for treatments of many diseases. However, due to their poor stability and permeability in the gastrointestinal tract, the oral bioavailability of peptide drugs is negligible. Nanoparticle formulations have been proposed to circumven...

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Detalles Bibliográficos
Autores principales: Lundquist, Patrik, Khodus, Georgiy, Niu, Zhigao, Thwala, Lungile Nomcebo, McCartney, Fiona, Simoff, Ivailo, Andersson, Ellen, Beloqui, Ana, Mabondzo, Aloise, Robla, Sandra, Webb, Dominic-Luc, Hellström, Per M., Keita, Åsa V, Sima, Eduardo, Csaba, Noemi, Sundbom, Magnus, Preat, Veronique, Brayden, David J., Alonso, Maria Jose, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527806/
https://www.ncbi.nlm.nih.gov/pubmed/35998570
http://dx.doi.org/10.1021/acsnano.2c04330

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