Cargando…

Role of NINJ1 in Gout Flare and Potential as a Drug Target

OBJECTIVE: To determine the role of nerve injury-induced protein 1 (NINJ1) introduced plasma membrane rupture (PMR) and damage-associated molecular patterns (DAMPs) release in the pathogenesis and progression of gout and to explore the potential of NINJ1 as a therapeutic target in gout. METHODS: Bot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hongliang, Gao, Jie, Fang, Wenxiang, Tang, Yujie, Fang, Xuan, Jin, Tengchuan, Tao, Jinhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527815/ https://www.ncbi.nlm.nih.gov/pubmed/36199745 http://dx.doi.org/10.2147/JIR.S378341

Ejemplares similares

Purinergic Signaling in the Regulation of Gout Flare and Resolution
por: Li, Xiaoling, et al.
Publicado: (2021)

Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection
por: Sheng, Yixuan, et al.
Publicado: (2023)

The challenges of gout flare reporting: mapping flares during a randomized controlled trial
por: Teoh, Novell, et al.
Publicado: (2019)

Treatment for acute flares of gout: A protocol for systematic review
por: Tang, Hongzhi, et al.
Publicado: (2020)

Comparison of Benzbromarone and Allopurinol on Primary Prevention of the First Gout Flare in Asymptomatic Hyperuricemia
por: Lai, Shih-Wei, et al.
Publicado: (2022)

Serum CA72-4 is specifically elevated in gout patients and predicts flares
por: Bai, Xueshan, et al.
Publicado: (2020)

Changes of serum uric acid level during acute gout flare and related factors
por: Zhang, Jie, et al.
Publicado: (2023)

Gout Flares and Mortality After Sodium-Glucose Cotransporter-2 Inhibitor Treatment for Gout and Type 2 Diabetes
por: Wei, Jie, et al.
Publicado: (2023)

Fluctuation and change of serum urate levels and flares in gout: results from the NOR-Gout study
por: Uhlig, T., et al.
Publicado: (2022)

Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
por: Kayagaki, Nobuhiko, et al.
Publicado: (2023)

Gout, flares, and allopurinol use: a population-based study
por: Proudman, Charlotte, et al.
Publicado: (2019)

Joint Application of Multiple Inflammatory Cytokines in Diagnosis of Gout Flare
por: Yu, Hanqing, et al.
Publicado: (2023)

An Atypical Presentation of a Polyarticular Gout Flare: Case Report
por: Londono, Larua, et al.
Publicado: (2023)

Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case–control study
por: Zhu, Yanping, et al.
Publicado: (2014)

One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study
por: Uhlig, Till, et al.
Publicado: (2022)

Dysmyelination by Oligodendrocyte‐Specific Ablation of Ninj2 Contributes to Depressive‐Like Behaviors
por: Sun, Yuxia, et al.
Publicado: (2021)

Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling
por: Sun, Yuxia, et al.
Publicado: (2022)

NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation
por: Zhou, Xiaoli, et al.
Publicado: (2023)

Structural basis of NINJ1-mediated plasma membrane rupture in cell death
por: Degen, Morris, et al.
Publicado: (2023)

Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination
por: Lu, Jie, et al.
Publicado: (2022)

Patient and clinical characteristics associated with gout flares in an integrated healthcare system
por: Rashid, Nazia, et al.
Publicado: (2015)

Risk Factors for Postsurgical Gout Flares after Thoracolumbar Spine Surgeries
por: Chen, Kuan-Jung, et al.
Publicado: (2022)

Cohort study investigating gout flares and management in UK general practice
por: Finnikin, Samuel, et al.
Publicado: (2023)

Tele-monitoring flares using a smartphone app in patients with gout or suspected gout: a feasibility study
por: Pouls, Bart P H, et al.
Publicado: (2021)

Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial
por: Stamp, Lisa K., et al.
Publicado: (2022)

Monosodium urate burden assessed with dual-energy computed tomography predicts the risk of flares in gout: a 12-month observational study: MSU burden and risk of gout flare
por: Pascart, Tristan, et al.
Publicado: (2018)

Risk of gout flares after COVID-19 vaccination: A case-crossover study
por: Li, Hui, et al.
Publicado: (2022)

Comparison of an interactive voice response system and smartphone application in the identification of gout flares
por: Elmagboul, Nada, et al.
Publicado: (2019)

miR‐3146 induces neutrophil extracellular traps to aggravate gout flare
por: Shan, Lizhen, et al.
Publicado: (2021)

The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment
por: Tong, Shuting, et al.
Publicado: (2022)

Involvement of NINJ2 Protein in Inflammation and Blood–Brain Barrier Transmigration of Monocytes in Multiple Sclerosis
por: Sorosina, Melissa, et al.
Publicado: (2022)

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
por: Borges, Jazlyn P, et al.
Publicado: (2022)

Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk
por: Yan, Shouchun, et al.
Publicado: (2023)

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis
por: Dondelinger, Yves, et al.
Publicado: (2023)

The role of dual energy computed tomography in the differentiation of acute gout flares and acute calcium pyrophosphate crystal arthritis
por: Kravchenko, Dmitrij, et al.
Publicado: (2021)

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
por: Bjanes, Elisabet, et al.
Publicado: (2021)

ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares
por: Lee, Chi-Pin, et al.
Publicado: (2016)

Physical activity measured using wearable activity tracking devices associated with gout flares
por: Elmagboul, Nada, et al.
Publicado: (2020)

Septic Arthritis Complicating a Gout Flare: Report of Two Cases and Review of the Literature
por: Tzanis, Prokopios, et al.
Publicado: (2022)

The Effect of Decrease in Serum Urate for the Risk of Gout Flares During Urate-Lowering Therapy Initiation Among Chinese Male Gout Patients: A Prospective Cohort Study
por: Pang, Lei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ugeucgc8nmtukqr4brg807mvf1