Cargando…
Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report
Painful post-traumatic trigeminal neuropathy (PPTTN) can result from iatrogenic injury to one or more branches of the trigeminal nerve during oral surgical procedures such as tooth extractions. Like other chronic neuropathic pain conditions, PPTTN can significantly alter the patient’s quality of lif...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528003/ https://www.ncbi.nlm.nih.gov/pubmed/36172992 http://dx.doi.org/10.1177/03000605211047704 |
_version_ | 1784801201681858560 |
---|---|
author | Capon, Chloé Crevant, Aurélien Pointin, Armelle Sulukdjian, Arek Moreau, Nathan |
author_facet | Capon, Chloé Crevant, Aurélien Pointin, Armelle Sulukdjian, Arek Moreau, Nathan |
author_sort | Capon, Chloé |
collection | PubMed |
description | Painful post-traumatic trigeminal neuropathy (PPTTN) can result from iatrogenic injury to one or more branches of the trigeminal nerve during oral surgical procedures such as tooth extractions. Like other chronic neuropathic pain conditions, PPTTN can significantly alter the patient’s quality of life, especially when pharmacological treatment is ineffective or not tolerated. As such, new treatment options have been investigated, including local injections of botulinum toxin type A (BTX-A). A 29-year-old woman presented to our tertiary orofacial pain clinic for evaluation of chronic electric shock-like pain attacks and severe allodynia in the territory of the right inferior alveolar nerve and buccal nerve following right mandibular third molar extraction 3 years prior. Following several failed attempts at classic pharmacological management (including carbamazepine, venlafaxine, duloxetine, pregabalin, clonazepam, and amitriptyline), BTX-A injections were administered in the vicinity of the right mental nerve. This treatment provided significant improvement in the patient’s condition and overall quality of life with no significant adverse effects. Because both neuropathies were significantly improved by remote BTX-A injections, this case report provides preliminary clinical evidence supporting spinopetal transport of BTX-A, as shown in animal models, as an underlying pathophysiological mechanism of BTX-A-mediated analgesia. |
format | Online Article Text |
id | pubmed-9528003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-95280032022-10-04 Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report Capon, Chloé Crevant, Aurélien Pointin, Armelle Sulukdjian, Arek Moreau, Nathan J Int Med Res Case Reports Painful post-traumatic trigeminal neuropathy (PPTTN) can result from iatrogenic injury to one or more branches of the trigeminal nerve during oral surgical procedures such as tooth extractions. Like other chronic neuropathic pain conditions, PPTTN can significantly alter the patient’s quality of life, especially when pharmacological treatment is ineffective or not tolerated. As such, new treatment options have been investigated, including local injections of botulinum toxin type A (BTX-A). A 29-year-old woman presented to our tertiary orofacial pain clinic for evaluation of chronic electric shock-like pain attacks and severe allodynia in the territory of the right inferior alveolar nerve and buccal nerve following right mandibular third molar extraction 3 years prior. Following several failed attempts at classic pharmacological management (including carbamazepine, venlafaxine, duloxetine, pregabalin, clonazepam, and amitriptyline), BTX-A injections were administered in the vicinity of the right mental nerve. This treatment provided significant improvement in the patient’s condition and overall quality of life with no significant adverse effects. Because both neuropathies were significantly improved by remote BTX-A injections, this case report provides preliminary clinical evidence supporting spinopetal transport of BTX-A, as shown in animal models, as an underlying pathophysiological mechanism of BTX-A-mediated analgesia. SAGE Publications 2022-09-29 /pmc/articles/PMC9528003/ /pubmed/36172992 http://dx.doi.org/10.1177/03000605211047704 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Reports Capon, Chloé Crevant, Aurélien Pointin, Armelle Sulukdjian, Arek Moreau, Nathan Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
title | Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
title_full | Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
title_fullStr | Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
title_full_unstemmed | Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
title_short | Botulinum toxin A for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
title_sort | botulinum toxin a for management of refractory concurrent buccal and inferior alveolar nerve post-traumatic neuropathies: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528003/ https://www.ncbi.nlm.nih.gov/pubmed/36172992 http://dx.doi.org/10.1177/03000605211047704 |
work_keys_str_mv | AT caponchloe botulinumtoxinaformanagementofrefractoryconcurrentbuccalandinferioralveolarnerveposttraumaticneuropathiesacasereport AT crevantaurelien botulinumtoxinaformanagementofrefractoryconcurrentbuccalandinferioralveolarnerveposttraumaticneuropathiesacasereport AT pointinarmelle botulinumtoxinaformanagementofrefractoryconcurrentbuccalandinferioralveolarnerveposttraumaticneuropathiesacasereport AT sulukdjianarek botulinumtoxinaformanagementofrefractoryconcurrentbuccalandinferioralveolarnerveposttraumaticneuropathiesacasereport AT moreaunathan botulinumtoxinaformanagementofrefractoryconcurrentbuccalandinferioralveolarnerveposttraumaticneuropathiesacasereport |