The role of macrophage subtypes and exosomes in immunomodulation

Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage...

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Autores principales: Gharavi, Abdulwahab Teflischi, Hanjani, Niloofar Asadi, Movahed, Elaheh, Doroudian, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528143/
https://www.ncbi.nlm.nih.gov/pubmed/36192691
http://dx.doi.org/10.1186/s11658-022-00384-y
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author Gharavi, Abdulwahab Teflischi
Hanjani, Niloofar Asadi
Movahed, Elaheh
Doroudian, Mohammad
author_facet Gharavi, Abdulwahab Teflischi
Hanjani, Niloofar Asadi
Movahed, Elaheh
Doroudian, Mohammad
author_sort Gharavi, Abdulwahab Teflischi
collection PubMed
description Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage polarization plays a key role in the initiation and development of a wide range of diseases. This study aims to give an overview of macrophage polarization, their different subtypes, and the importance of alternatively activated M2 macrophage and classically activated M1 macrophage in immune responses and pathological conditions. This review provides insight on the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate.
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spelling pubmed-95281432022-10-04 The role of macrophage subtypes and exosomes in immunomodulation Gharavi, Abdulwahab Teflischi Hanjani, Niloofar Asadi Movahed, Elaheh Doroudian, Mohammad Cell Mol Biol Lett Review Letter Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage polarization plays a key role in the initiation and development of a wide range of diseases. This study aims to give an overview of macrophage polarization, their different subtypes, and the importance of alternatively activated M2 macrophage and classically activated M1 macrophage in immune responses and pathological conditions. This review provides insight on the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate. BioMed Central 2022-10-03 /pmc/articles/PMC9528143/ /pubmed/36192691 http://dx.doi.org/10.1186/s11658-022-00384-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Letter
Gharavi, Abdulwahab Teflischi
Hanjani, Niloofar Asadi
Movahed, Elaheh
Doroudian, Mohammad
The role of macrophage subtypes and exosomes in immunomodulation
title The role of macrophage subtypes and exosomes in immunomodulation
title_full The role of macrophage subtypes and exosomes in immunomodulation
title_fullStr The role of macrophage subtypes and exosomes in immunomodulation
title_full_unstemmed The role of macrophage subtypes and exosomes in immunomodulation
title_short The role of macrophage subtypes and exosomes in immunomodulation
title_sort role of macrophage subtypes and exosomes in immunomodulation
topic Review Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528143/
https://www.ncbi.nlm.nih.gov/pubmed/36192691
http://dx.doi.org/10.1186/s11658-022-00384-y
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