Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

BACKGROUND: During normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres. RESULTS: Contrary to this fundamental biological tenet, we demonstrate here that parental genomes can segregate to distinct blastomeres during the zygotic...

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Detalles Bibliográficos
Autores principales: De Coster, Tine, Masset, Heleen, Tšuiko, Olga, Catteeuw, Maaike, Zhao, Yan, Dierckxsens, Nicolas, Aparicio, Ainhoa Larreategui, Dimitriadou, Eftychia, Debrock, Sophie, Peeraer, Karen, de Ruijter-Villani, Marta, Smits, Katrien, Van Soom, Ann, Vermeesch, Joris Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528162/
https://www.ncbi.nlm.nih.gov/pubmed/36184650
http://dx.doi.org/10.1186/s13059-022-02763-2

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