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Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis

Although tuberculosis (TB) is a serious public health concern, we still don’t understand why only 10% of people infected will develop the disease. Apoptosis plays a role in the interaction of Mycobacterium tuberculosis (Mtb) with the human host and it may be modified by subtle alterations in the B-c...

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Autores principales: He, Juan, Liu, Shengyuan, Guo, Xujun, Zhang, Fan, Takiff, Howard Eugene, Zhao, Yashuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical de São Paulo 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528363/
https://www.ncbi.nlm.nih.gov/pubmed/36197420
http://dx.doi.org/10.1590/S1678-9946202264059
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author He, Juan
Liu, Shengyuan
Guo, Xujun
Zhang, Fan
Takiff, Howard Eugene
Zhao, Yashuang
author_facet He, Juan
Liu, Shengyuan
Guo, Xujun
Zhang, Fan
Takiff, Howard Eugene
Zhao, Yashuang
author_sort He, Juan
collection PubMed
description Although tuberculosis (TB) is a serious public health concern, we still don’t understand why only 10% of people infected will develop the disease. Apoptosis plays a role in the interaction of Mycobacterium tuberculosis (Mtb) with the human host and it may be modified by subtle alterations in the B-cell lymphoma 2 (BCL2) gene, an anti-apoptotic regulatory element. Therefore, we investigated whether there is an association between BCL2 polymorphisms and susceptibility to TB by analyzing 130 TB cases, 108 subjects with latent TB infection (LTBI), and 163 healthy controls (HC). Logistic regression was used to calculate odds ratios (ORs) and 95% confidential intervals (95% CIs) for possible associations between single nucleotide polymorphisms (SNPs) in BCL2 and the risk of tuberculosis. We found that the G allele of rs80030866 (OR=0.62, 95%CI:0.42-0.91, P=0.015), and also the G allele of rs9955190 (OR=0.58, 95%CI:0.38-0.88, P=0.011) were less frequent in the TB group compared with the LTBI group. In addition, individuals with rs2551402 CC genotype were more likely to have LTBI than those with AA genotype (OR=2.166, 95%CI:1.046-4.484, P=0.037). Our study suggests that BCL2 gene polymorphisms may be correlated with susceptibility to both TB and LTBI.
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spelling pubmed-95283632022-10-17 Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis He, Juan Liu, Shengyuan Guo, Xujun Zhang, Fan Takiff, Howard Eugene Zhao, Yashuang Rev Inst Med Trop Sao Paulo Original Article Although tuberculosis (TB) is a serious public health concern, we still don’t understand why only 10% of people infected will develop the disease. Apoptosis plays a role in the interaction of Mycobacterium tuberculosis (Mtb) with the human host and it may be modified by subtle alterations in the B-cell lymphoma 2 (BCL2) gene, an anti-apoptotic regulatory element. Therefore, we investigated whether there is an association between BCL2 polymorphisms and susceptibility to TB by analyzing 130 TB cases, 108 subjects with latent TB infection (LTBI), and 163 healthy controls (HC). Logistic regression was used to calculate odds ratios (ORs) and 95% confidential intervals (95% CIs) for possible associations between single nucleotide polymorphisms (SNPs) in BCL2 and the risk of tuberculosis. We found that the G allele of rs80030866 (OR=0.62, 95%CI:0.42-0.91, P=0.015), and also the G allele of rs9955190 (OR=0.58, 95%CI:0.38-0.88, P=0.011) were less frequent in the TB group compared with the LTBI group. In addition, individuals with rs2551402 CC genotype were more likely to have LTBI than those with AA genotype (OR=2.166, 95%CI:1.046-4.484, P=0.037). Our study suggests that BCL2 gene polymorphisms may be correlated with susceptibility to both TB and LTBI. Instituto de Medicina Tropical de São Paulo 2022-09-30 /pmc/articles/PMC9528363/ /pubmed/36197420 http://dx.doi.org/10.1590/S1678-9946202264059 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
He, Juan
Liu, Shengyuan
Guo, Xujun
Zhang, Fan
Takiff, Howard Eugene
Zhao, Yashuang
Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis
title Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis
title_full Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis
title_fullStr Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis
title_full_unstemmed Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis
title_short Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis
title_sort polymorphisms of the bcl2 gene associated with susceptibility to tuberculosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528363/
https://www.ncbi.nlm.nih.gov/pubmed/36197420
http://dx.doi.org/10.1590/S1678-9946202264059
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