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Ironing out exercise on immuno-oncological outcomes
Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is unknown. Cancer cells have greater metabolic require...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528609/ https://www.ncbi.nlm.nih.gov/pubmed/36180069 http://dx.doi.org/10.1136/jitc-2021-002976 |
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author | Soh, Janjira Lim, Zi Xiang Lim, Elaine Hsuen Kennedy, Brian K Goh, Jorming |
author_facet | Soh, Janjira Lim, Zi Xiang Lim, Elaine Hsuen Kennedy, Brian K Goh, Jorming |
author_sort | Soh, Janjira |
collection | PubMed |
description | Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is unknown. Cancer cells have greater metabolic requirements than normal cells, with their survival and proliferation depending largely on iron bioavailability. Although iron is an essential mineral for mitogenesis, it also participates in a form of iron-dependent programmed cell death termed ferroptosis. In this short hypothesis paper, we speculate that modulating iron bioavailability, transport and metabolism with regular exercise can have significant implications for tumor and stromal cells in the tumor microenvironment, by affecting multiple tumor-autonomous and stromal cell responses. |
format | Online Article Text |
id | pubmed-9528609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-95286092022-10-04 Ironing out exercise on immuno-oncological outcomes Soh, Janjira Lim, Zi Xiang Lim, Elaine Hsuen Kennedy, Brian K Goh, Jorming J Immunother Cancer Hypothesis Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is unknown. Cancer cells have greater metabolic requirements than normal cells, with their survival and proliferation depending largely on iron bioavailability. Although iron is an essential mineral for mitogenesis, it also participates in a form of iron-dependent programmed cell death termed ferroptosis. In this short hypothesis paper, we speculate that modulating iron bioavailability, transport and metabolism with regular exercise can have significant implications for tumor and stromal cells in the tumor microenvironment, by affecting multiple tumor-autonomous and stromal cell responses. BMJ Publishing Group 2022-09-30 /pmc/articles/PMC9528609/ /pubmed/36180069 http://dx.doi.org/10.1136/jitc-2021-002976 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Hypothesis Soh, Janjira Lim, Zi Xiang Lim, Elaine Hsuen Kennedy, Brian K Goh, Jorming Ironing out exercise on immuno-oncological outcomes |
title | Ironing out exercise on immuno-oncological outcomes |
title_full | Ironing out exercise on immuno-oncological outcomes |
title_fullStr | Ironing out exercise on immuno-oncological outcomes |
title_full_unstemmed | Ironing out exercise on immuno-oncological outcomes |
title_short | Ironing out exercise on immuno-oncological outcomes |
title_sort | ironing out exercise on immuno-oncological outcomes |
topic | Hypothesis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528609/ https://www.ncbi.nlm.nih.gov/pubmed/36180069 http://dx.doi.org/10.1136/jitc-2021-002976 |
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