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Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

BACKGROUND: We previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). However, induction of systemic antitumor immunity by HS201...

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Detalles Bibliográficos
Autores principales:	Kaneko, Kensuke, Acharya, Chaitanya R, Nagata, Hiroshi, Yang, Xiao, Hartman, Zachary Conrad, Hobeika, Amy, Hughes, Philip F, Haystead, Timothy A J, Morse, Michael A, Lyerly, Herbert Kim, Osada, Takuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528636/ https://www.ncbi.nlm.nih.gov/pubmed/36171008 http://dx.doi.org/10.1136/jitc-2022-004793

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