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Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma

BACKGROUND: We previously reported results from a phase 1 study testing intratumoral recombinant poliovirus, lerapolturev, in 12 melanoma patients. All 12 patients received anti-PD-1 systemic therapy before lerapolturev, and 11 of these 12 patients also received anti-PD-1 after lerapolturev. In prec...

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Detalles Bibliográficos
Autores principales:	Beasley, Georgia M, Brown, Michael C, Farrow, Norma E, Landa, Karenia, Al-Rohil, Rami N, Selim, Maria Angelica, Therien, Aaron D, Jung, Sin-Ho, Gao, Junheng, Boczkowski, David, Holl, Eda K, Salama, April K S, Bigner, Darell D, Gromeier, Matthias, Nair, Smita K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528663/ https://www.ncbi.nlm.nih.gov/pubmed/36175036 http://dx.doi.org/10.1136/jitc-2022-005052

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