The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis

Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral...

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Autores principales: Cordeiro, Patrícia Azevedo Soares, Assone, Tatiane, Prates, Gabriela, Tedeschi, Marcia Regina Martinez, Fonseca, Luiz Augusto Marcondes, Casseb, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical de São Paulo 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528752/
https://www.ncbi.nlm.nih.gov/pubmed/36197425
http://dx.doi.org/10.1590/S1678-9946202264064
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author Cordeiro, Patrícia Azevedo Soares
Assone, Tatiane
Prates, Gabriela
Tedeschi, Marcia Regina Martinez
Fonseca, Luiz Augusto Marcondes
Casseb, Jorge
author_facet Cordeiro, Patrícia Azevedo Soares
Assone, Tatiane
Prates, Gabriela
Tedeschi, Marcia Regina Martinez
Fonseca, Luiz Augusto Marcondes
Casseb, Jorge
author_sort Cordeiro, Patrícia Azevedo Soares
collection PubMed
description Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.
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spelling pubmed-95287522022-10-17 The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis Cordeiro, Patrícia Azevedo Soares Assone, Tatiane Prates, Gabriela Tedeschi, Marcia Regina Martinez Fonseca, Luiz Augusto Marcondes Casseb, Jorge Rev Inst Med Trop Sao Paulo Review Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health. Instituto de Medicina Tropical de São Paulo 2022-09-30 /pmc/articles/PMC9528752/ /pubmed/36197425 http://dx.doi.org/10.1590/S1678-9946202264064 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cordeiro, Patrícia Azevedo Soares
Assone, Tatiane
Prates, Gabriela
Tedeschi, Marcia Regina Martinez
Fonseca, Luiz Augusto Marcondes
Casseb, Jorge
The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
title The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
title_full The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
title_fullStr The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
title_full_unstemmed The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
title_short The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
title_sort role of ifn-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528752/
https://www.ncbi.nlm.nih.gov/pubmed/36197425
http://dx.doi.org/10.1590/S1678-9946202264064
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