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Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study

INTRODUCTION: Weight loss after bariatric surgery is attributed, at least in part, to the altered gastrointestinal (GI) hormone secretion, which is thought to be responsible for a number of beneficial metabolic effects. MATERIAL AND METHODS: We conducted a cross-sectional study. Twelve patients who...

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Autores principales: Lampropoulos, Charalampos, Mulita, Francesk, Alexandrides, Theodoros, Kehagias, Dimitrios, Kalavrizioti, Dimitra, Albanopoulos, Konstantinos, Georgopoulos, Neoklis, Papachristou, Evangelos, Kehagias, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528819/
https://www.ncbi.nlm.nih.gov/pubmed/36199737
http://dx.doi.org/10.5114/pm.2022.116492
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author Lampropoulos, Charalampos
Mulita, Francesk
Alexandrides, Theodoros
Kehagias, Dimitrios
Kalavrizioti, Dimitra
Albanopoulos, Konstantinos
Georgopoulos, Neoklis
Papachristou, Evangelos
Kehagias, Ioannis
author_facet Lampropoulos, Charalampos
Mulita, Francesk
Alexandrides, Theodoros
Kehagias, Dimitrios
Kalavrizioti, Dimitra
Albanopoulos, Konstantinos
Georgopoulos, Neoklis
Papachristou, Evangelos
Kehagias, Ioannis
author_sort Lampropoulos, Charalampos
collection PubMed
description INTRODUCTION: Weight loss after bariatric surgery is attributed, at least in part, to the altered gastrointestinal (GI) hormone secretion, which is thought to be responsible for a number of beneficial metabolic effects. MATERIAL AND METHODS: We conducted a cross-sectional study. Twelve patients who underwent laparoscopic sleeve gastrectomy (SG) and 20 patients who underwent a variant of biliopancreatic diversion with Roux-en-Y gastric bypass and long limbs (BPD/RYGB-LL) were evaluated ≥ 7 years postoperatively. Ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) secretion were compared between patients with successful weight loss maintenance (WM group) and patients with weight regain (WR group). RESULTS: In both types of surgery, standard liquid mixed meal (SLMM) ingestion did not result in significant changes in fasting GI hormone levels. Fasting ghrelin levels did not differ between the WM group and the WR group in both types of surgery. In SG patients, SLMM ingestion elicited greater suppression of ghrelin levels in the WM group (p = 0.032). No difference in GLP-1 secretion was observed between the 2 groups of patients in both types of surgery. When patients were examined, regardless of the type of bariatric surgery they had undergone, postprandial PYY levels were lower in the WM group (p < 0.05), while fasting and postprandial PYY levels were correlated positively with an increase in body mass index (BMI) in the evaluation (Spearman’s rho ≥ 0.395, p < 0.03). CONCLUSIONS: Our data do not support the hypothesis that long-term weight regain after bariatric surgery is associated with an unfavourable GI hormone secretion pattern.
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spelling pubmed-95288192022-10-04 Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study Lampropoulos, Charalampos Mulita, Francesk Alexandrides, Theodoros Kehagias, Dimitrios Kalavrizioti, Dimitra Albanopoulos, Konstantinos Georgopoulos, Neoklis Papachristou, Evangelos Kehagias, Ioannis Prz Menopauzalny Original Paper INTRODUCTION: Weight loss after bariatric surgery is attributed, at least in part, to the altered gastrointestinal (GI) hormone secretion, which is thought to be responsible for a number of beneficial metabolic effects. MATERIAL AND METHODS: We conducted a cross-sectional study. Twelve patients who underwent laparoscopic sleeve gastrectomy (SG) and 20 patients who underwent a variant of biliopancreatic diversion with Roux-en-Y gastric bypass and long limbs (BPD/RYGB-LL) were evaluated ≥ 7 years postoperatively. Ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) secretion were compared between patients with successful weight loss maintenance (WM group) and patients with weight regain (WR group). RESULTS: In both types of surgery, standard liquid mixed meal (SLMM) ingestion did not result in significant changes in fasting GI hormone levels. Fasting ghrelin levels did not differ between the WM group and the WR group in both types of surgery. In SG patients, SLMM ingestion elicited greater suppression of ghrelin levels in the WM group (p = 0.032). No difference in GLP-1 secretion was observed between the 2 groups of patients in both types of surgery. When patients were examined, regardless of the type of bariatric surgery they had undergone, postprandial PYY levels were lower in the WM group (p < 0.05), while fasting and postprandial PYY levels were correlated positively with an increase in body mass index (BMI) in the evaluation (Spearman’s rho ≥ 0.395, p < 0.03). CONCLUSIONS: Our data do not support the hypothesis that long-term weight regain after bariatric surgery is associated with an unfavourable GI hormone secretion pattern. Termedia Publishing House 2022-06-08 2022-06 /pmc/articles/PMC9528819/ /pubmed/36199737 http://dx.doi.org/10.5114/pm.2022.116492 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Lampropoulos, Charalampos
Mulita, Francesk
Alexandrides, Theodoros
Kehagias, Dimitrios
Kalavrizioti, Dimitra
Albanopoulos, Konstantinos
Georgopoulos, Neoklis
Papachristou, Evangelos
Kehagias, Ioannis
Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
title Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
title_full Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
title_fullStr Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
title_full_unstemmed Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
title_short Ghrelin, glucagon-like peptide-1, and peptide YY secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
title_sort ghrelin, glucagon-like peptide-1, and peptide yy secretion in patients with and without weight regain during long-term follow-up after bariatric surgery: a cross-sectional study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528819/
https://www.ncbi.nlm.nih.gov/pubmed/36199737
http://dx.doi.org/10.5114/pm.2022.116492
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