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Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature

Gestational trophoblastic disease (GTD) covers a range of proliferative disorders from non-neoplastic hydatid moles to malignant neoplastic conditions such as choriocarcinoma. The incidence of these diseases is low and often challenging to diagnose. Placental site trophoblastic tumour (PSTT) is the...

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Autores principales: Yordanov, Angel, Strateva, Diana, Kostov, Stoyan, Kornovski, Yavor, Slavchev, Stanislav, Ivanova, Yonka, Nikolova, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528820/
https://www.ncbi.nlm.nih.gov/pubmed/36199742
http://dx.doi.org/10.5114/pm.2022.116502
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author Yordanov, Angel
Strateva, Diana
Kostov, Stoyan
Kornovski, Yavor
Slavchev, Stanislav
Ivanova, Yonka
Nikolova, Margarita
author_facet Yordanov, Angel
Strateva, Diana
Kostov, Stoyan
Kornovski, Yavor
Slavchev, Stanislav
Ivanova, Yonka
Nikolova, Margarita
author_sort Yordanov, Angel
collection PubMed
description Gestational trophoblastic disease (GTD) covers a range of proliferative disorders from non-neoplastic hydatid moles to malignant neoplastic conditions such as choriocarcinoma. The incidence of these diseases is low and often challenging to diagnose. Placental site trophoblastic tumour (PSTT) is the rarest form of GTD, accounting for up to 3% of all cases. We present a case of a 35-year-old patient diagnosed with PSTT mimicking an intramural pregnancy. Placental site trophoblastic tumour occurred after pregnancy, which ended as a blighted ovum. β-hCG was not very high, and the patient had no complaints. The diagnosis was made after resection of formation which was accepted for intramural pregnancy. To our knowledge, this is the first such case described in the literature. A hysterectomy performed later confirmed the absence of a residual tumour after conservative intervention. The lack of distant metastases, confirmed by positron emission tomography-computed tomography scan, allowed for only hysterectomy with bilateral salpingo-oophorectomy to be performed. The patient was classified as low risk according to the World Health Organization (WHO) scoring system. Placental site trophoblastic tumour is a rare malignant tumour (despite its WHO coding) from the group of GTDs. It is not presented with a classic clinical picture, and its clinical diagnosis is challenging. However, clinicians should consider it in the case of unclear events after any type of pregnancy.
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spelling pubmed-95288202022-10-04 Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature Yordanov, Angel Strateva, Diana Kostov, Stoyan Kornovski, Yavor Slavchev, Stanislav Ivanova, Yonka Nikolova, Margarita Prz Menopauzalny Case Report Gestational trophoblastic disease (GTD) covers a range of proliferative disorders from non-neoplastic hydatid moles to malignant neoplastic conditions such as choriocarcinoma. The incidence of these diseases is low and often challenging to diagnose. Placental site trophoblastic tumour (PSTT) is the rarest form of GTD, accounting for up to 3% of all cases. We present a case of a 35-year-old patient diagnosed with PSTT mimicking an intramural pregnancy. Placental site trophoblastic tumour occurred after pregnancy, which ended as a blighted ovum. β-hCG was not very high, and the patient had no complaints. The diagnosis was made after resection of formation which was accepted for intramural pregnancy. To our knowledge, this is the first such case described in the literature. A hysterectomy performed later confirmed the absence of a residual tumour after conservative intervention. The lack of distant metastases, confirmed by positron emission tomography-computed tomography scan, allowed for only hysterectomy with bilateral salpingo-oophorectomy to be performed. The patient was classified as low risk according to the World Health Organization (WHO) scoring system. Placental site trophoblastic tumour is a rare malignant tumour (despite its WHO coding) from the group of GTDs. It is not presented with a classic clinical picture, and its clinical diagnosis is challenging. However, clinicians should consider it in the case of unclear events after any type of pregnancy. Termedia Publishing House 2022-05-30 2022-06 /pmc/articles/PMC9528820/ /pubmed/36199742 http://dx.doi.org/10.5114/pm.2022.116502 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Case Report
Yordanov, Angel
Strateva, Diana
Kostov, Stoyan
Kornovski, Yavor
Slavchev, Stanislav
Ivanova, Yonka
Nikolova, Margarita
Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
title Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
title_full Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
title_fullStr Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
title_full_unstemmed Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
title_short Placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
title_sort placental site trophoblastic tumour mimicking an intramural pregnancy: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528820/
https://www.ncbi.nlm.nih.gov/pubmed/36199742
http://dx.doi.org/10.5114/pm.2022.116502
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