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Dynamic subcortical modulators of human default mode network function
The brain’s “default mode network” (DMN) enables flexible switching between internally and externally focused cognition. Precisely how this modulation occurs is not well understood, although it may involve key subcortical mechanisms, including hypothesized influences from the basal forebrain (BF) an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528899/ https://www.ncbi.nlm.nih.gov/pubmed/34974620 http://dx.doi.org/10.1093/cercor/bhab487 |
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author | Harrison, Ben J Davey, Christopher G Savage, Hannah S Jamieson, Alec J Leonards, Christine A Moffat, Bradford A Glarin, Rebecca K Steward, Trevor |
author_facet | Harrison, Ben J Davey, Christopher G Savage, Hannah S Jamieson, Alec J Leonards, Christine A Moffat, Bradford A Glarin, Rebecca K Steward, Trevor |
author_sort | Harrison, Ben J |
collection | PubMed |
description | The brain’s “default mode network” (DMN) enables flexible switching between internally and externally focused cognition. Precisely how this modulation occurs is not well understood, although it may involve key subcortical mechanisms, including hypothesized influences from the basal forebrain (BF) and mediodorsal thalamus (MD). Here, we used ultra-high field (7 T) functional magnetic resonance imaging to examine the involvement of the BF and MD across states of task-induced DMN activity modulation. Specifically, we mapped DMN activity suppression (“deactivation”) when participants transitioned between rest and externally focused task performance, as well as DMN activity engagement (“activation”) when task performance was internally (i.e., self) focused. Consistent with recent rodent studies, the BF showed overall activity suppression with DMN cortical regions when comparing the rest to external task conditions. Further analyses, including dynamic causal modeling, confirmed that the BF drove changes in DMN cortical activity during these rest-to-task transitions. The MD, by comparison, was specifically engaged during internally focused cognition and demonstrated a broad excitatory influence on DMN cortical activation. These results provide the first direct evidence in humans of distinct BF and thalamic circuit influences on the control of DMN function and suggest novel mechanistic avenues for ongoing translational research. |
format | Online Article Text |
id | pubmed-9528899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95288992022-10-04 Dynamic subcortical modulators of human default mode network function Harrison, Ben J Davey, Christopher G Savage, Hannah S Jamieson, Alec J Leonards, Christine A Moffat, Bradford A Glarin, Rebecca K Steward, Trevor Cereb Cortex Original Article The brain’s “default mode network” (DMN) enables flexible switching between internally and externally focused cognition. Precisely how this modulation occurs is not well understood, although it may involve key subcortical mechanisms, including hypothesized influences from the basal forebrain (BF) and mediodorsal thalamus (MD). Here, we used ultra-high field (7 T) functional magnetic resonance imaging to examine the involvement of the BF and MD across states of task-induced DMN activity modulation. Specifically, we mapped DMN activity suppression (“deactivation”) when participants transitioned between rest and externally focused task performance, as well as DMN activity engagement (“activation”) when task performance was internally (i.e., self) focused. Consistent with recent rodent studies, the BF showed overall activity suppression with DMN cortical regions when comparing the rest to external task conditions. Further analyses, including dynamic causal modeling, confirmed that the BF drove changes in DMN cortical activity during these rest-to-task transitions. The MD, by comparison, was specifically engaged during internally focused cognition and demonstrated a broad excitatory influence on DMN cortical activation. These results provide the first direct evidence in humans of distinct BF and thalamic circuit influences on the control of DMN function and suggest novel mechanistic avenues for ongoing translational research. Oxford University Press 2021-12-31 /pmc/articles/PMC9528899/ /pubmed/34974620 http://dx.doi.org/10.1093/cercor/bhab487 Text en © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Harrison, Ben J Davey, Christopher G Savage, Hannah S Jamieson, Alec J Leonards, Christine A Moffat, Bradford A Glarin, Rebecca K Steward, Trevor Dynamic subcortical modulators of human default mode network function |
title | Dynamic subcortical modulators of human default mode network function |
title_full | Dynamic subcortical modulators of human default mode network function |
title_fullStr | Dynamic subcortical modulators of human default mode network function |
title_full_unstemmed | Dynamic subcortical modulators of human default mode network function |
title_short | Dynamic subcortical modulators of human default mode network function |
title_sort | dynamic subcortical modulators of human default mode network function |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528899/ https://www.ncbi.nlm.nih.gov/pubmed/34974620 http://dx.doi.org/10.1093/cercor/bhab487 |
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