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Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor

In recent years, a growing number of clinical studies have shown that immune checkpoint inhibitor (ICI) can increase the remission rate and improve the prognosis of patients with esophageal cancer. The Controlling Nutritional Status (CONUT) score is a novel nutritional indicator that can predict the...

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Autores principales: Chang, Lele, Cheng, Qian, Ma, Yue, Wu, Chunlong, Zhang, Xuemei, Ma, Qian, He, Lei, Li, Qingwei, Tao, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528939/
https://www.ncbi.nlm.nih.gov/pubmed/36006239
http://dx.doi.org/10.1097/CJI.0000000000000438
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author Chang, Lele
Cheng, Qian
Ma, Yue
Wu, Chunlong
Zhang, Xuemei
Ma, Qian
He, Lei
Li, Qingwei
Tao, Ji
author_facet Chang, Lele
Cheng, Qian
Ma, Yue
Wu, Chunlong
Zhang, Xuemei
Ma, Qian
He, Lei
Li, Qingwei
Tao, Ji
author_sort Chang, Lele
collection PubMed
description In recent years, a growing number of clinical studies have shown that immune checkpoint inhibitor (ICI) can increase the remission rate and improve the prognosis of patients with esophageal cancer. The Controlling Nutritional Status (CONUT) score is a novel nutritional indicator that can predict the prognosis of certain malignancies. We retrospectively analyzed the clinical data of 69 patients with advanced esophageal cancer treated with ICI and assessed the relationship between clinicopathological factors including CONUT score, systemic immune-inflammatory index (SII), and neutrophil-to-lymphocyte ratio and the prognosis. We found the CONUT score and SII, neutrophil-to-lymphocyte ratio were an independent prognostic factor for overall survival (P<0.05). Furthermore, among patients treated with ICI, a high CONUT score was associated with a significantly worse progression-free survival (PFS) and overall survival compared with a low CONUT group. In conclusion, the CONUT can be used to predict the efficacy and prognosis of ICI therapy in patients with esophageal cancer. Our studies have shown that the CONUT score can be used as an effective indicator for the prognosis of patients with esophageal cancer receiving ICI.
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spelling pubmed-95289392022-10-11 Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor Chang, Lele Cheng, Qian Ma, Yue Wu, Chunlong Zhang, Xuemei Ma, Qian He, Lei Li, Qingwei Tao, Ji J Immunother Clinical Studies In recent years, a growing number of clinical studies have shown that immune checkpoint inhibitor (ICI) can increase the remission rate and improve the prognosis of patients with esophageal cancer. The Controlling Nutritional Status (CONUT) score is a novel nutritional indicator that can predict the prognosis of certain malignancies. We retrospectively analyzed the clinical data of 69 patients with advanced esophageal cancer treated with ICI and assessed the relationship between clinicopathological factors including CONUT score, systemic immune-inflammatory index (SII), and neutrophil-to-lymphocyte ratio and the prognosis. We found the CONUT score and SII, neutrophil-to-lymphocyte ratio were an independent prognostic factor for overall survival (P<0.05). Furthermore, among patients treated with ICI, a high CONUT score was associated with a significantly worse progression-free survival (PFS) and overall survival compared with a low CONUT group. In conclusion, the CONUT can be used to predict the efficacy and prognosis of ICI therapy in patients with esophageal cancer. Our studies have shown that the CONUT score can be used as an effective indicator for the prognosis of patients with esophageal cancer receiving ICI. Lippincott Williams & Wilkins 2022 2022-08-26 /pmc/articles/PMC9528939/ /pubmed/36006239 http://dx.doi.org/10.1097/CJI.0000000000000438 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Clinical Studies
Chang, Lele
Cheng, Qian
Ma, Yue
Wu, Chunlong
Zhang, Xuemei
Ma, Qian
He, Lei
Li, Qingwei
Tao, Ji
Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor
title Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor
title_full Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor
title_fullStr Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor
title_full_unstemmed Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor
title_short Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor
title_sort prognostic effect of the controlling nutritional status score in patients with esophageal cancer treated with immune checkpoint inhibitor
topic Clinical Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528939/
https://www.ncbi.nlm.nih.gov/pubmed/36006239
http://dx.doi.org/10.1097/CJI.0000000000000438
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