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Learning probabilistic protein–DNA recognition codes from DNA-binding specificities using structural mappings
Knowledge of how proteins interact with DNA is essential for understanding gene regulation. Although DNA-binding specificities for thousands of transcription factors (TFs) have been determined, the specific amino acid–base interactions comprising their structural interfaces are largely unknown. This...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528988/ https://www.ncbi.nlm.nih.gov/pubmed/36123148 http://dx.doi.org/10.1101/gr.276606.122 |