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Pharmacokinetics of Herb-Drug Interactions of Plumbagin and Tazemetostat in Rats by UPLC-MS/MS

OBJECTIVE: A sensitive and rapid UPLC-MS/MS method for determination of tazemetostat in rat plasma was developed, and the pharmacokinetics of herb-drug interactions (HDIs) of plumbagin (PLB) and tazemetostat was investigated. METHODS: After the rat plasma samples were precipitated by acetonitrile, t...

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Detalles Bibliográficos
Autores principales:	Li, Heng, Wang, Ying-Jie, Geng, Xiao-Nan, Kang, Yao-Ren, Wang, Yi-Lin, Qiu, Xiang-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529013/ https://www.ncbi.nlm.nih.gov/pubmed/36199632 http://dx.doi.org/10.2147/DDDT.S384156

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