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The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

Investment in SARS-CoV-2 sequencing in Africa over the past year has led to a major increase in the number of sequences generated, now exceeding 100,000 genomes, used to track the pandemic on the continent. Our results show an increase in the number of African countries able to sequence domestically...

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Detalles Bibliográficos
Autores principales: Tegally, Houriiyah, San, James E., Cotten, Matthew, Moir, Monika, Tegomoh, Bryan, Mboowa, Gerald, Martin, Darren P., Baxter, Cheryl, Lambisia, Arnold W., Diallo, Amadou, Amoako, Daniel G., Diagne, Moussa M., Sisay, Abay, Zekri, Abdel-Rahman N., Gueye, Abdou Salam, Sangare, Abdoul K., Ouedraogo, Abdoul-Salam, Sow, Abdourahmane, Musa, Abdualmoniem O., Sesay, Abdul K., Abias, Abe G., Elzagheid, Adam I., Lagare, Adamou, Kemi, Adedotun-Sulaiman, Abar, Aden Elmi, Johnson, Adeniji A., Fowotade, Adeola, Oluwapelumi, Adeyemi O., Amuri, Adrienne A., Juru, Agnes, Kandeil, Ahmed, Mostafa, Ahmed, Rebai, Ahmed, Sayed, Ahmed, Kazeem, Akano, Balde, Aladje, Christoffels, Alan, Trotter, Alexander J., Campbell, Allan, Keita, Alpha K., Kone, Amadou, Bouzid, Amal, Souissi, Amal, Agweyu, Ambrose, Naguib, Amel, Gutierrez, Ana V., Nkeshimana, Anatole, Page, Andrew J., Yadouleton, Anges, Vinze, Anika, Happi, Anise N., Chouikha, Anissa, Iranzadeh, Arash, Maharaj, Arisha, Batchi-Bouyou, Armel L., Ismail, Arshad, Sylverken, Augustina A., Goba, Augustine, Femi, Ayoade, Sijuwola, Ayotunde E., Marycelin, Baba, Salako, Babatunde L., Oderinde, Bamidele S., Bolajoko, Bankole, Diarra, Bassirou, Herring, Belinda L., Tsofa, Benjamin, Lekana-Douki, Bernard, Mvula, Bernard, Njanpop-Lafourcade, Berthe-Marie, Marondera, Blessing T., Khaireh, Bouh Abdi, Kouriba, Bourema, Adu, Bright, Pool, Brigitte, McInnis, Bronwyn, Brook, Cara, Williamson, Carolyn, Nduwimana, Cassien, Anscombe, Catherine, Pratt, Catherine B., Scheepers, Cathrine, Akoua-Koffi, Chantal G., Agoti, Charles N., Mapanguy, Chastel M., Loucoubar, Cheikh, Onwuamah, Chika K., Ihekweazu, Chikwe, Malaka, Christian N., Peyrefitte, Christophe, Grace, Chukwa, Omoruyi, Chukwuma E., Rafaï, Clotaire D., Morang’a, Collins M., Erameh, Cyril, Lule, Daniel B., Bridges, Daniel J., Mukadi-Bamuleka, Daniel, Park, Danny, Rasmussen, David A., Baker, David, Nokes, David J., Ssemwanga, Deogratius, Tshiabuila, Derek, Amuzu, Dominic S. Y., Goedhals, Dominique, Grant, Donald S., Omuoyo, Donwilliams O., Maruapula, Dorcas, Wanjohi, Dorcas W., Foster-Nyarko, Ebenezer, Lusamaki, Eddy K., Simulundu, Edgar, Ong’era, Edidah M., Ngabana, Edith N., Abworo, Edward O., Otieno, Edward, Shumba, Edwin, Barasa, Edwine, Ahmed, El Bara, Ahmed, Elhadi A., Lokilo, Emmanuel, Mukantwari, Enatha, Philomena, Eromon, Belarbi, Essia, Simon-Loriere, Etienne, Anoh, Etilé A., Manuel, Eusebio, Leendertz, Fabian, Taweh, Fahn M., Wasfi, Fares, Abdelmoula, Fatma, Takawira, Faustinos T., Derrar, Fawzi, Ajogbasile, Fehintola V., Treurnicht, Florette, Onikepe, Folarin, Ntoumi, Francine, Muyembe, Francisca M., Ragomzingba, Frank E. Z., Dratibi, Fred A., Iyanu, Fred-Akintunwa, Mbunsu, Gabriel K., Thilliez, Gaetan, Kay, Gemma L., Akpede, George O., van Zyl, Gert U., Awandare, Gordon A., Kpeli, Grace S., Schubert, Grit, Maphalala, Gugu P., Ranaivoson, Hafaliana C., Omunakwe, Hannah E., Onywera, Harris, Abe, Haruka, Karray, Hela, Nansumba, Hellen, Triki, Henda, Kadjo, Herve Albéric Adje, Elgahzaly, Hesham, Gumbo, Hlanai, Mathieu, Hota, Kavunga-Membo, Hugo, Smeti, Ibtihel, Olawoye, Idowu B., Adetifa, Ifedayo M. O., Odia, Ikponmwosa, Ben Boubaker, Ilhem Boutiba, Mohammad, Iluoreh Ahmed, Ssewanyana, Isaac, Wurie, Isatta, Konstantinus, Iyaloo S., Halatoko, Jacqueline Wemboo Afiwa, Ayei, James, Sonoo, Janaki, Makangara, Jean-Claude C., Tamfum, Jean-Jacques M., Heraud, Jean-Michel, Shaffer, Jeffrey G., Giandhari, Jennifer, Musyoki, Jennifer, Nkurunziza, Jerome, Uwanibe, Jessica N., Bhiman, Jinal N., Yasuda, Jiro, Morais, Joana, Kiconco, Jocelyn, Sandi, John D., Huddleston, John, Odoom, John K., Morobe, John M., Gyapong, John O., Kayiwa, John T., Okolie, Johnson C., Xavier, Joicymara S., Gyamfi, Jones, Wamala, Joseph F., Bonney, Joseph H. K., Nyandwi, Joseph, Everatt, Josie, Nakaseegu, Joweria, Ngoi, Joyce M., Namulondo, Joyce, Oguzie, Judith U., Andeko, Julia C., Lutwama, Julius J., Mogga, Juma J. H., O’Grady, Justin, Siddle, Katherine J., Victoir, Kathleen, Adeyemi, Kayode T., Tumedi, Kefentse A., Carvalho, Kevin S., Mohammed, Khadija Said, Dellagi, Koussay, Musonda, Kunda G., Duedu, Kwabena O., Fki-Berrajah, Lamia, Singh, Lavanya, Kepler, Lenora M., Biscornet, Leon, de Oliveira Martins, Leonardo, Chabuka, Lucious, Olubayo, Luicer, Ojok, Lul Deng, Deng, Lul Lojok, Ochola-Oyier, Lynette I., Tyers, Lynn, Mine, Madisa, Ramuth, Magalutcheemee, Mastouri, Maha, ElHefnawi, Mahmoud, Mbanne, Maimouna, Matsheka, Maitshwarelo I., Kebabonye, Malebogo, Diop, Mamadou, Momoh, Mambu, Lima Mendonça, Maria da Luz, Venter, Marietjie, Paye, Marietou F., Faye, Martin, Nyaga, Martin M., Mareka, Mathabo, Damaris, Matoke-Muhia, Mburu, Maureen W., Mpina, Maximillian G., Owusu, Michael, Wiley, Michael R., Tatfeng, Mirabeau Y., Ayekaba, Mitoha Ondo’o, Abouelhoda, Mohamed, Beloufa, Mohamed Amine, Seadawy, Mohamed G., Khalifa, Mohamed K., Matobo, Mooko Marethabile, Kane, Mouhamed, Salou, Mounerou, Mbulawa, Mphaphi B., Mwenda, Mulenga, Allam, Mushal, Phan, My V. T., Abid, Nabil, Rujeni, Nadine, Abuzaid, Nadir, Ismael, Nalia, Elguindy, Nancy, Top, Ndeye Marieme, Dia, Ndongo, Mabunda, Nédio, Hsiao, Nei-yuan, Silochi, Nelson Boricó, Francisco, Ngiambudulu M., Saasa, Ngonda, Bbosa, Nicholas, Murunga, Nickson, Gumede, Nicksy, Wolter, Nicole, Sitharam, Nikita, Ndodo, Nnaemeka, Ajayi, Nnennaya A., Tordo, Noël, Mbhele, Nokuzola, Razanajatovo, Norosoa H., Iguosadolo, Nosamiefan, Mba, Nwando, Kingsley, Ojide C., Sylvanus, Okogbenin, Femi, Oladiji, Adewumi, Olubusuyi M., Testimony, Olumade, Ogunsanya, Olusola A., Fakayode, Oluwatosin, Ogah, Onwe E., Oludayo, Ope-Ewe, Faye, Ousmane, Smith-Lawrence, Pamela, Ondoa, Pascale, Combe, Patrice, Nabisubi, Patricia, Semanda, Patrick, Oluniyi, Paul E., Arnaldo, Paulo, Quashie, Peter Kojo, Okokhere, Peter O., Bejon, Philip, Dussart, Philippe, Bester, Phillip A., Mbala, Placide K., Kaleebu, Pontiano, Abechi, Priscilla, El-Shesheny, Rabeh, Joseph, Rageema, Aziz, Ramy Karam, Essomba, René G., Ayivor-Djanie, Reuben, Njouom, Richard, Phillips, Richard O., Gorman, Richmond, Kingsley, Robert A., Neto Rodrigues, Rosa Maria D. E. S. A., Audu, Rosemary A., Carr, Rosina A. A., Gargouri, Saba, Masmoudi, Saber, Bootsma, Sacha, Sankhe, Safietou, Mohamed, Sahra Isse, Femi, Saibu, Mhalla, Salma, Hosch, Salome, Kassim, Samar Kamal, Metha, Samar, Trabelsi, Sameh, Agwa, Sara Hassan, Mwangi, Sarah Wambui, Doumbia, Seydou, Makiala-Mandanda, Sheila, Aryeetey, Sherihane, Ahmed, Shymaa S., Ahmed, Side Mohamed, Elhamoumi, Siham, Moyo, Sikhulile, Lutucuta, Silvia, Gaseitsiwe, Simani, Jalloh, Simbirie, Andriamandimby, Soa Fy, Oguntope, Sobajo, Grayo, Solène, Lekana-Douki, Sonia, Prosolek, Sophie, Ouangraoua, Soumeya, van Wyk, Stephanie, Schaffner, Stephen F., Kanyerezi, Stephen, Ahuka-Mundeke, Steve, Rudder, Steven, Pillay, Sureshnee, Nabadda, Susan, Behillil, Sylvie, Budiaki, Sylvie L., van der Werf, Sylvie, Mashe, Tapfumanei, Mohale, Thabo, Le-Viet, Thanh, Velavan, Thirumalaisamy P., Schindler, Tobias, Maponga, Tongai G., Bedford, Trevor, Anyaneji, Ugochukwu J., Chinedu, Ugwu, Ramphal, Upasana, George, Uwem E., Enouf, Vincent, Nene, Vishvanath, Gorova, Vivianne, Roshdy, Wael H., Karim, Wasim Abdul, Ampofo, William K., Preiser, Wolfgang, Choga, Wonderful T., Ahmed, Yahaya Ali, Ramphal, Yajna, Bediako, Yaw, Naidoo, Yeshnee, Butera, Yvan, de Laurent, Zaydah R., Ouma, Ahmed E. O., von Gottberg, Anne, Githinji, George, Moeti, Matshidiso, Tomori, Oyewale, Sabeti, Pardis C., Sall, Amadou A., Oyola, Samuel O., Tebeje, Yenew K., Tessema, Sofonias K., de Oliveira, Tulio, Happi, Christian, Lessells, Richard, Nkengasong, John, Wilkinson, Eduan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529057/
https://www.ncbi.nlm.nih.gov/pubmed/36108049
http://dx.doi.org/10.1126/science.abq5358
Descripción
Sumario:Investment in SARS-CoV-2 sequencing in Africa over the past year has led to a major increase in the number of sequences generated, now exceeding 100,000 genomes, used to track the pandemic on the continent. Our results show an increase in the number of African countries able to sequence domestically, and highlight that local sequencing enables faster turnaround time and more regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and shed light on the distinct dispersal dynamics of Variants of Concern, particularly Alpha, Beta, Delta, and Omicron, on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve, while the continent faces many emerging and re-emerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century.