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Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors
INTRODUCTION & BACKGROUND: Prolonged (duration >7 to 13 days) diarrhea (ProD) in under-five children is a universal health problem including Bangladesh. Data on epidemiology and associated or risk factors of ProD are limited, particularly in Bangladesh where a high burden of ProD is reported....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529139/ https://www.ncbi.nlm.nih.gov/pubmed/36190936 http://dx.doi.org/10.1371/journal.pone.0273148 |
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author | Hossain, Md. Iqbal Faruque, A. S. G. Sarmin, Monira Chisti, Mohammod Jobayer Ahmed, Tahmeed |
author_facet | Hossain, Md. Iqbal Faruque, A. S. G. Sarmin, Monira Chisti, Mohammod Jobayer Ahmed, Tahmeed |
author_sort | Hossain, Md. Iqbal |
collection | PubMed |
description | INTRODUCTION & BACKGROUND: Prolonged (duration >7 to 13 days) diarrhea (ProD) in under-five children is a universal health problem including Bangladesh. Data on epidemiology and associated or risk factors of ProD are limited, particularly in Bangladesh where a high burden of ProD is reported. This study intended to assess the case load of ProD and its associated or risk factors compared to acute diarrhea (AD, duration ≤7 days). METHODS: We analyzed the data collected between 1996–2014 from a hospital-based Diarrheal-Disease-Surveillance-System (DDSS) in the ‘Dhaka Hospital’ of International Centre for Diarrhoeal Diseases, Bangladesh (icddr,b). The DDSS enrolled a 2% systematic sample, regardless of age, sex, and diarrhea severity. The data included information on socio-demographic factors, environmental history, clinical characteristics, nutritional status, and diarrhea-pathogens. After cleaning of data, relevant information of 21,566 under-five children were available who reported with ≤13 days diarrhea (including AD and ProD), and their data were analyzed. Variables found significantly associated with ProD compared to AD in bi-variate analysis were used in logistic regression model after checking the multicollinearity between independent variables. RESULTS: The mean±SD age of the children was 14.9±11.7 months and 40.4% were female; 7.6% had ProD and 92.4% had AD. Age <12 months, mucoid- or bloody-stool, warmer months (April-September), drug used at home before seeking care from hospital, and history of diarrhea within last one month were found associated with ProD (p<0.05); however, rotavirus infection was less common in children with ProD (p<0.05). ProD children more often needed inpatient admission than AD children (14.4 vs. 6.3, p<0.001). Case fatality rate of ProD vs. AD was 0.3% (n = 5) vs. 0.1% (n- = 22) respectively (p = 0.051). CONCLUSION: A considerable proportion (7.6%) of under-five children reporting to icddr,b hospital suffered from ProD. Understanding the above-mentioned associated or risk factors is likely to help policy makers formulating appropriate strategies for alleviating the burden and effectively managing ProD in under-five children. |
format | Online Article Text |
id | pubmed-9529139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95291392022-10-04 Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors Hossain, Md. Iqbal Faruque, A. S. G. Sarmin, Monira Chisti, Mohammod Jobayer Ahmed, Tahmeed PLoS One Research Article INTRODUCTION & BACKGROUND: Prolonged (duration >7 to 13 days) diarrhea (ProD) in under-five children is a universal health problem including Bangladesh. Data on epidemiology and associated or risk factors of ProD are limited, particularly in Bangladesh where a high burden of ProD is reported. This study intended to assess the case load of ProD and its associated or risk factors compared to acute diarrhea (AD, duration ≤7 days). METHODS: We analyzed the data collected between 1996–2014 from a hospital-based Diarrheal-Disease-Surveillance-System (DDSS) in the ‘Dhaka Hospital’ of International Centre for Diarrhoeal Diseases, Bangladesh (icddr,b). The DDSS enrolled a 2% systematic sample, regardless of age, sex, and diarrhea severity. The data included information on socio-demographic factors, environmental history, clinical characteristics, nutritional status, and diarrhea-pathogens. After cleaning of data, relevant information of 21,566 under-five children were available who reported with ≤13 days diarrhea (including AD and ProD), and their data were analyzed. Variables found significantly associated with ProD compared to AD in bi-variate analysis were used in logistic regression model after checking the multicollinearity between independent variables. RESULTS: The mean±SD age of the children was 14.9±11.7 months and 40.4% were female; 7.6% had ProD and 92.4% had AD. Age <12 months, mucoid- or bloody-stool, warmer months (April-September), drug used at home before seeking care from hospital, and history of diarrhea within last one month were found associated with ProD (p<0.05); however, rotavirus infection was less common in children with ProD (p<0.05). ProD children more often needed inpatient admission than AD children (14.4 vs. 6.3, p<0.001). Case fatality rate of ProD vs. AD was 0.3% (n = 5) vs. 0.1% (n- = 22) respectively (p = 0.051). CONCLUSION: A considerable proportion (7.6%) of under-five children reporting to icddr,b hospital suffered from ProD. Understanding the above-mentioned associated or risk factors is likely to help policy makers formulating appropriate strategies for alleviating the burden and effectively managing ProD in under-five children. Public Library of Science 2022-10-03 /pmc/articles/PMC9529139/ /pubmed/36190936 http://dx.doi.org/10.1371/journal.pone.0273148 Text en © 2022 Hossain et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hossain, Md. Iqbal Faruque, A. S. G. Sarmin, Monira Chisti, Mohammod Jobayer Ahmed, Tahmeed Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors |
title | Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors |
title_full | Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors |
title_fullStr | Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors |
title_full_unstemmed | Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors |
title_short | Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors |
title_sort | prolonged diarrhea among under-five children in bangladesh: burden and risk factors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529139/ https://www.ncbi.nlm.nih.gov/pubmed/36190936 http://dx.doi.org/10.1371/journal.pone.0273148 |
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