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Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination

Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elder...

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Autores principales: Hafızoğlu, Merve, Bas, Arzu Okyar, Tavukçuoğlu, Ece, Sahiner, Zeynep, Oytun, Merve Güner, Ulutürk, Sıla, Yanık, Hamdullah, Doğu, Burcu Balam, Cankurtaran, Mustafa, Esendağlı, Güneş, Akbıyık, Filiz, Çakır, Banu, Ünal, Serhat, Halil, Meltem Gülhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529214/
https://www.ncbi.nlm.nih.gov/pubmed/38013969
http://dx.doi.org/10.1016/j.clicom.2022.09.005
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author Hafızoğlu, Merve
Bas, Arzu Okyar
Tavukçuoğlu, Ece
Sahiner, Zeynep
Oytun, Merve Güner
Ulutürk, Sıla
Yanık, Hamdullah
Doğu, Burcu Balam
Cankurtaran, Mustafa
Esendağlı, Güneş
Akbıyık, Filiz
Çakır, Banu
Ünal, Serhat
Halil, Meltem Gülhan
author_facet Hafızoğlu, Merve
Bas, Arzu Okyar
Tavukçuoğlu, Ece
Sahiner, Zeynep
Oytun, Merve Güner
Ulutürk, Sıla
Yanık, Hamdullah
Doğu, Burcu Balam
Cankurtaran, Mustafa
Esendağlı, Güneş
Akbıyık, Filiz
Çakır, Banu
Ünal, Serhat
Halil, Meltem Gülhan
author_sort Hafızoğlu, Merve
collection PubMed
description Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4(+) and CD8(+) memory T cell proliferation and IFN-γ production capacities were evaluated. Additionally, clinical frailty scale (CFS) and FRAIL scales of the individuals were scored. CD4(+) memory T cell responses more prominent than CD8(+) memory T cells. In seronegative individuals, 80% of them had memory CD4(+) and IFN-γ, whereas 50% of them had memory CD4(+) and all of them had IFN-γ responses. Additionally, 40% of seronegative patients and 50% of seropositive patients had memory CD8(+) responses. To sum up, humoral immune responses are not associated with memory T cell responses, and in seronegative individuals, memory T cell responses can be detected.
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spelling pubmed-95292142022-10-04 Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination Hafızoğlu, Merve Bas, Arzu Okyar Tavukçuoğlu, Ece Sahiner, Zeynep Oytun, Merve Güner Ulutürk, Sıla Yanık, Hamdullah Doğu, Burcu Balam Cankurtaran, Mustafa Esendağlı, Güneş Akbıyık, Filiz Çakır, Banu Ünal, Serhat Halil, Meltem Gülhan Clinical Immunology Communications Article Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4(+) and CD8(+) memory T cell proliferation and IFN-γ production capacities were evaluated. Additionally, clinical frailty scale (CFS) and FRAIL scales of the individuals were scored. CD4(+) memory T cell responses more prominent than CD8(+) memory T cells. In seronegative individuals, 80% of them had memory CD4(+) and IFN-γ, whereas 50% of them had memory CD4(+) and all of them had IFN-γ responses. Additionally, 40% of seronegative patients and 50% of seropositive patients had memory CD8(+) responses. To sum up, humoral immune responses are not associated with memory T cell responses, and in seronegative individuals, memory T cell responses can be detected. The Authors. Published by Elsevier Inc. 2022-12 2022-09-29 /pmc/articles/PMC9529214/ /pubmed/38013969 http://dx.doi.org/10.1016/j.clicom.2022.09.005 Text en © 2022 The Authors. Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hafızoğlu, Merve
Bas, Arzu Okyar
Tavukçuoğlu, Ece
Sahiner, Zeynep
Oytun, Merve Güner
Ulutürk, Sıla
Yanık, Hamdullah
Doğu, Burcu Balam
Cankurtaran, Mustafa
Esendağlı, Güneş
Akbıyık, Filiz
Çakır, Banu
Ünal, Serhat
Halil, Meltem Gülhan
Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
title Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
title_full Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
title_fullStr Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
title_full_unstemmed Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
title_short Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
title_sort memory t cell responses in seronegative older adults following sars-cov-2 vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529214/
https://www.ncbi.nlm.nih.gov/pubmed/38013969
http://dx.doi.org/10.1016/j.clicom.2022.09.005
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