The differential roles of the two NO-GC isoforms in adjusting airway reactivity

The enzyme, nitric oxide-sensitive guanylyl cyclase (NO-GC), is activated by binding NO to its prosthetic heme group and catalyzes the formation of cGMP. The NO-GC is primarily known to mediate vascular smooth muscle relaxation in the lung, and inhaled NO has been successfully used as a selective pu...

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Detalles Bibliográficos
Autores principales: Verheyen, Malte, Puschkarow, Michelle, Gnipp, Stefanie, Koesling, Doris, Peters, Marcus, Mergia, Evanthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529264/
https://www.ncbi.nlm.nih.gov/pubmed/35972838
http://dx.doi.org/10.1152/ajplung.00404.2021

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