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Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population
Genetic variations are critical for understanding clinical outcomes of infections including server acute respiratory syndrome coronavirus 2 (SARS CoV-2). The immunological reactions of human immune genes with SARS CoV-2 have been under investigation. Toll-like receptors (TLRs), a group of proteins,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529343/ https://www.ncbi.nlm.nih.gov/pubmed/37521442 http://dx.doi.org/10.1016/j.humgen.2022.201115 |
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author | Ali, Hussein N. Niranji, Sherko S. Al-Jaf, Sirwan M.A. |
author_facet | Ali, Hussein N. Niranji, Sherko S. Al-Jaf, Sirwan M.A. |
author_sort | Ali, Hussein N. |
collection | PubMed |
description | Genetic variations are critical for understanding clinical outcomes of infections including server acute respiratory syndrome coronavirus 2 (SARS CoV-2). The immunological reactions of human immune genes with SARS CoV-2 have been under investigation. Toll-like receptors (TLRs), a group of proteins, are important for microbial detections including bacteria and viruses. TLR4 can sense both bacterial lipopolysaccharides (LPS) and endogenous oxidized phospholipids triggered by Covid-19 infection. Two TLR4 single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile have been linked to infectious diseases. No studies have focused on these SNPs in association with Covid-19. This study aims to reveal the association between Covid-19 infection with these SNPs by comparing a group of patients and a general population. Restriction fragment length polymorphisms (RFLP) were used to identify the TLR4 SNPs in both the general population (n = 114) and Covid-19 patient groups (n = 125). The results found no association between the TLR4 polymorphisms and Covid-19 infections as the data showed no statistically significant difference between the compared groups. This suggested that these TLR4 SNPs may not be associated with Covid-19 infections. |
format | Online Article Text |
id | pubmed-9529343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95293432022-10-04 Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population Ali, Hussein N. Niranji, Sherko S. Al-Jaf, Sirwan M.A. Human Gene Article Genetic variations are critical for understanding clinical outcomes of infections including server acute respiratory syndrome coronavirus 2 (SARS CoV-2). The immunological reactions of human immune genes with SARS CoV-2 have been under investigation. Toll-like receptors (TLRs), a group of proteins, are important for microbial detections including bacteria and viruses. TLR4 can sense both bacterial lipopolysaccharides (LPS) and endogenous oxidized phospholipids triggered by Covid-19 infection. Two TLR4 single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile have been linked to infectious diseases. No studies have focused on these SNPs in association with Covid-19. This study aims to reveal the association between Covid-19 infection with these SNPs by comparing a group of patients and a general population. Restriction fragment length polymorphisms (RFLP) were used to identify the TLR4 SNPs in both the general population (n = 114) and Covid-19 patient groups (n = 125). The results found no association between the TLR4 polymorphisms and Covid-19 infections as the data showed no statistically significant difference between the compared groups. This suggested that these TLR4 SNPs may not be associated with Covid-19 infections. Elsevier B.V. 2022-12 2022-10-04 /pmc/articles/PMC9529343/ /pubmed/37521442 http://dx.doi.org/10.1016/j.humgen.2022.201115 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ali, Hussein N. Niranji, Sherko S. Al-Jaf, Sirwan M.A. Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population |
title | Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population |
title_full | Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population |
title_fullStr | Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population |
title_full_unstemmed | Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population |
title_short | Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population |
title_sort | association of toll-like receptor-4 polymorphism with sars cov-2 infection in kurdish population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529343/ https://www.ncbi.nlm.nih.gov/pubmed/37521442 http://dx.doi.org/10.1016/j.humgen.2022.201115 |
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