Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation

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The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 is responsible for compaction of the ∼30-kb RNA genome in the ∼90-nm virion. Previous studies suggest that each virion contains 35 to 40 viral ribonucleoprotein (vRNP) complexes, or ribonucleosomes, arrayed along the gen...

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Detalles Bibliográficos
Autores principales: Carlson, Christopher R., Adly, Armin N., Bi, Maxine, Howard, Conor J., Frost, Adam, Cheng, Yifan, Morgan, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529352/
https://www.ncbi.nlm.nih.gov/pubmed/36202211
http://dx.doi.org/10.1016/j.jbc.2022.102560
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