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Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain

The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered d...

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Autores principales: Rotimi, Damilare Emmanuel, Ben-Goru, Goodnews Mavoghenegbero, Evbuomwan, Ikponmwosa Owen, Elebiyo, Tobiloba Christiana, Alorabi, Mohammed, Farasani, Abdullah, Batiha, Gaber El-Saber, Adeyemi, Oluyomi Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529415/
https://www.ncbi.nlm.nih.gov/pubmed/36199544
http://dx.doi.org/10.1155/2022/9470178
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author Rotimi, Damilare Emmanuel
Ben-Goru, Goodnews Mavoghenegbero
Evbuomwan, Ikponmwosa Owen
Elebiyo, Tobiloba Christiana
Alorabi, Mohammed
Farasani, Abdullah
Batiha, Gaber El-Saber
Adeyemi, Oluyomi Stephen
author_facet Rotimi, Damilare Emmanuel
Ben-Goru, Goodnews Mavoghenegbero
Evbuomwan, Ikponmwosa Owen
Elebiyo, Tobiloba Christiana
Alorabi, Mohammed
Farasani, Abdullah
Batiha, Gaber El-Saber
Adeyemi, Oluyomi Stephen
author_sort Rotimi, Damilare Emmanuel
collection PubMed
description The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered distilled water (1 mL), while the test groups were orally administered 5 mg/mL of either Z. officinale, V. amygdalina infusion, or a combination of both, respectively, for 7 days. The rats were sacrificed at the end of treatments and blood and tissue were harvested and prepared for biochemical assays. Results showed that administration of V. amygdalina and Z. officinale, as well as their coadministration, reduced the levels of malondialdehyde (MDA), nitric oxide (NO), acetylcholinesterase (AChE), and myeloperoxidase (MPO) in rat brain tissue compared with the control group. Conversely, coadministration of V. amygdalina and Z. officinale increased the levels of reduced glutathione (GSH) in rat brain tissue compared with the control group. However, the administration of the infusions singly, as well as the combination of both infusions, did not have any effect on the rat brain levels of glutathione peroxidase (GPx) and catalase (CAT) antioxidant enzymes compared to the control. Taken together, the findings indicate that the V. amygdalina and Z. officinale tea infusions have favorable antioxidant properties in the rat brain. The findings are confirmatory and contribute to deepening our understanding of the health-promoting effects of V. amygdalina and Z. officinale tea infusions.
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spelling pubmed-95294152022-10-04 Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain Rotimi, Damilare Emmanuel Ben-Goru, Goodnews Mavoghenegbero Evbuomwan, Ikponmwosa Owen Elebiyo, Tobiloba Christiana Alorabi, Mohammed Farasani, Abdullah Batiha, Gaber El-Saber Adeyemi, Oluyomi Stephen Evid Based Complement Alternat Med Research Article The study investigated the effects of Zingiber officinale root and Vernonia amygdalina leaf on the brain redox status of Wistar rats. Twenty-four (24) rats weighing 160 ± 20 g were randomly assigned into four (4) groups, each with six (6) rats. Animals in Group 1 (control) were orally administered distilled water (1 mL), while the test groups were orally administered 5 mg/mL of either Z. officinale, V. amygdalina infusion, or a combination of both, respectively, for 7 days. The rats were sacrificed at the end of treatments and blood and tissue were harvested and prepared for biochemical assays. Results showed that administration of V. amygdalina and Z. officinale, as well as their coadministration, reduced the levels of malondialdehyde (MDA), nitric oxide (NO), acetylcholinesterase (AChE), and myeloperoxidase (MPO) in rat brain tissue compared with the control group. Conversely, coadministration of V. amygdalina and Z. officinale increased the levels of reduced glutathione (GSH) in rat brain tissue compared with the control group. However, the administration of the infusions singly, as well as the combination of both infusions, did not have any effect on the rat brain levels of glutathione peroxidase (GPx) and catalase (CAT) antioxidant enzymes compared to the control. Taken together, the findings indicate that the V. amygdalina and Z. officinale tea infusions have favorable antioxidant properties in the rat brain. The findings are confirmatory and contribute to deepening our understanding of the health-promoting effects of V. amygdalina and Z. officinale tea infusions. Hindawi 2022-09-26 /pmc/articles/PMC9529415/ /pubmed/36199544 http://dx.doi.org/10.1155/2022/9470178 Text en Copyright © 2022 Damilare Emmanuel Rotimi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rotimi, Damilare Emmanuel
Ben-Goru, Goodnews Mavoghenegbero
Evbuomwan, Ikponmwosa Owen
Elebiyo, Tobiloba Christiana
Alorabi, Mohammed
Farasani, Abdullah
Batiha, Gaber El-Saber
Adeyemi, Oluyomi Stephen
Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
title Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
title_full Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
title_fullStr Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
title_full_unstemmed Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
title_short Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain
title_sort zingiber officinale and vernonia amygdalina infusions improve redox status in rat brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529415/
https://www.ncbi.nlm.nih.gov/pubmed/36199544
http://dx.doi.org/10.1155/2022/9470178
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