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Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis

OBJECTIVES: Antisynthetase syndrome (ASS) and dermatomyositis (DM) are serious autoimmune diseases, with lungs being the most frequently involved organ and sometimes fatal. This study is aimed at clarifying the role of neutrophil-associated biological markers in suggesting ASS and DM-associated resp...

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Autores principales: Liu, Lei, Wang, Jundi, Zhang, Peiyu, Sun, Wenjia, Zhu, Xiuliang, Sun, Xiujuan, Xue, Jing, Wu, Huaxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529515/
https://www.ncbi.nlm.nih.gov/pubmed/36199667
http://dx.doi.org/10.1155/2022/1886083
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author Liu, Lei
Wang, Jundi
Zhang, Peiyu
Sun, Wenjia
Zhu, Xiuliang
Sun, Xiujuan
Xue, Jing
Wu, Huaxiang
author_facet Liu, Lei
Wang, Jundi
Zhang, Peiyu
Sun, Wenjia
Zhu, Xiuliang
Sun, Xiujuan
Xue, Jing
Wu, Huaxiang
author_sort Liu, Lei
collection PubMed
description OBJECTIVES: Antisynthetase syndrome (ASS) and dermatomyositis (DM) are serious autoimmune diseases, with lungs being the most frequently involved organ and sometimes fatal. This study is aimed at clarifying the role of neutrophil-associated biological markers in suggesting ASS and DM-associated respiratory infections and interstitial lung diseases. METHODS: We carried out a retrospective review of the medical records of 46 cases of ASS and DM diagnosed at the Second Hospital of Zhejiang University College of Medicine, between January 2017 and December 2020. Serum myeloperoxidase (MPO), neutrophil elastase (NE), α1 anti-trypsin (AAT), and interleukin-6 (IL-6) were also detected. RESULTS: Gottron's sign is characteristic of dermatomyositis, while polyarthritis is more characteristic of ASS. Pulmonary function is worse in ASS than in DM patients. Patients with ASS and DM had abnormal lymphocyte and neutrophil counts compared to healthy subjects, but not in relation to lung function and rapid progression of interstitial lung disease (RP-ILD). Elevated serum NE, MPO, and IL-6 levels are suggestive of respiratory infections, whereas decreased circulating IL-6 is predictive of RP-ILD. CONCLUSION: Our study identified the neutrophil-associated biomarkers MPO, NE, and IL-6 as promising indicators with different suggestive roles in respiratory infections and interstitial lung diseases in patients with ASS and DM.
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spelling pubmed-95295152022-10-04 Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis Liu, Lei Wang, Jundi Zhang, Peiyu Sun, Wenjia Zhu, Xiuliang Sun, Xiujuan Xue, Jing Wu, Huaxiang J Immunol Res Research Article OBJECTIVES: Antisynthetase syndrome (ASS) and dermatomyositis (DM) are serious autoimmune diseases, with lungs being the most frequently involved organ and sometimes fatal. This study is aimed at clarifying the role of neutrophil-associated biological markers in suggesting ASS and DM-associated respiratory infections and interstitial lung diseases. METHODS: We carried out a retrospective review of the medical records of 46 cases of ASS and DM diagnosed at the Second Hospital of Zhejiang University College of Medicine, between January 2017 and December 2020. Serum myeloperoxidase (MPO), neutrophil elastase (NE), α1 anti-trypsin (AAT), and interleukin-6 (IL-6) were also detected. RESULTS: Gottron's sign is characteristic of dermatomyositis, while polyarthritis is more characteristic of ASS. Pulmonary function is worse in ASS than in DM patients. Patients with ASS and DM had abnormal lymphocyte and neutrophil counts compared to healthy subjects, but not in relation to lung function and rapid progression of interstitial lung disease (RP-ILD). Elevated serum NE, MPO, and IL-6 levels are suggestive of respiratory infections, whereas decreased circulating IL-6 is predictive of RP-ILD. CONCLUSION: Our study identified the neutrophil-associated biomarkers MPO, NE, and IL-6 as promising indicators with different suggestive roles in respiratory infections and interstitial lung diseases in patients with ASS and DM. Hindawi 2022-09-26 /pmc/articles/PMC9529515/ /pubmed/36199667 http://dx.doi.org/10.1155/2022/1886083 Text en Copyright © 2022 Lei Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Lei
Wang, Jundi
Zhang, Peiyu
Sun, Wenjia
Zhu, Xiuliang
Sun, Xiujuan
Xue, Jing
Wu, Huaxiang
Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis
title Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis
title_full Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis
title_fullStr Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis
title_full_unstemmed Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis
title_short Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis
title_sort promising neutrophil-associated biomarkers in lung diseases of patients with antisynthetase syndrome and dermatomyositis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529515/
https://www.ncbi.nlm.nih.gov/pubmed/36199667
http://dx.doi.org/10.1155/2022/1886083
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