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A Fatal Etiology of Splenic Infarction

Hemophagocytic lymphohistiocytosis (HLH) is a rare systemic inflammatory disorder that is rapidly progressive and carries a poor prognosis. We present a case of HLH caused by undiagnosed B cell lymphoma, presenting initially with splenic infarction. Both HLH and splenic infarction are secondary cond...

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Detalles Bibliográficos
Autores principales: Masterman, David, Gandhi, Sonal, Singh, Amteshwar, Singh, Tanmay, Kaur, Ashampreet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Greater Baltimore Medical Center 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529637/
https://www.ncbi.nlm.nih.gov/pubmed/36262481
http://dx.doi.org/10.55729/2000-9666.1097
Descripción
Sumario:Hemophagocytic lymphohistiocytosis (HLH) is a rare systemic inflammatory disorder that is rapidly progressive and carries a poor prognosis. We present a case of HLH caused by undiagnosed B cell lymphoma, presenting initially with splenic infarction. Both HLH and splenic infarction are secondary conditions with a wide range of underlying etiologies. When either condition is identified, a prompt search for the underlying trigger is needed to prevent devastating consequences. We demonstrate the difficulties and barriers that can delay the diagnosis of HLH, and emphasize the importance of early treatment in improving survival rates.