Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis

Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7–2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab...

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Detalles Bibliográficos
Autores principales: Khan, Omair, Raashid, Sheharyar, Hashim, Muhammad, Clements, Kevin, Maheshwari, Sanjay, Mazhar Uddin, Syed M., Siriya, Pranay, Vadsariya, Aftab, Park, Patricia, Pascal, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Greater Baltimore Medical Center 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529648/
https://www.ncbi.nlm.nih.gov/pubmed/36262492
http://dx.doi.org/10.55729/2000-9666.1108
Descripción
Sumario:Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7–2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab investigations are necessary to reach the diagnosis. Surgical resection is the cornerstone of treatment in localized ACC; however, systemic chemotherapy with mitotane is preferred in patients with widespread disease or those who are not ideal candidates for surgery.

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