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Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis
Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7–2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Greater Baltimore Medical Center
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529648/ https://www.ncbi.nlm.nih.gov/pubmed/36262492 http://dx.doi.org/10.55729/2000-9666.1108 |
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author | Khan, Omair Raashid, Sheharyar Hashim, Muhammad Clements, Kevin Maheshwari, Sanjay Mazhar Uddin, Syed M. Siriya, Pranay Vadsariya, Aftab Park, Patricia Pascal, William |
author_facet | Khan, Omair Raashid, Sheharyar Hashim, Muhammad Clements, Kevin Maheshwari, Sanjay Mazhar Uddin, Syed M. Siriya, Pranay Vadsariya, Aftab Park, Patricia Pascal, William |
author_sort | Khan, Omair |
collection | PubMed |
description | Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7–2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab investigations are necessary to reach the diagnosis. Surgical resection is the cornerstone of treatment in localized ACC; however, systemic chemotherapy with mitotane is preferred in patients with widespread disease or those who are not ideal candidates for surgery. |
format | Online Article Text |
id | pubmed-9529648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Greater Baltimore Medical Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-95296482022-10-18 Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis Khan, Omair Raashid, Sheharyar Hashim, Muhammad Clements, Kevin Maheshwari, Sanjay Mazhar Uddin, Syed M. Siriya, Pranay Vadsariya, Aftab Park, Patricia Pascal, William J Community Hosp Intern Med Perspect Case Report Adrenocortical carcinoma (ACC) is a rare malignancy with an estimated annual incidence of 0.7–2 cases per million. Most patients present with steroid hormone excess or abdominal mass effects, but 15% of patients with ACC are diagnosed incidentally. A careful history, physical exam, and pertinent lab investigations are necessary to reach the diagnosis. Surgical resection is the cornerstone of treatment in localized ACC; however, systemic chemotherapy with mitotane is preferred in patients with widespread disease or those who are not ideal candidates for surgery. Greater Baltimore Medical Center 2022-09-09 /pmc/articles/PMC9529648/ /pubmed/36262492 http://dx.doi.org/10.55729/2000-9666.1108 Text en © 2022 Greater Baltimore Medical Center https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ). |
spellingShingle | Case Report Khan, Omair Raashid, Sheharyar Hashim, Muhammad Clements, Kevin Maheshwari, Sanjay Mazhar Uddin, Syed M. Siriya, Pranay Vadsariya, Aftab Park, Patricia Pascal, William Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis |
title | Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis |
title_full | Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis |
title_fullStr | Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis |
title_full_unstemmed | Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis |
title_short | Diagnosis of Adrenocortical Carcinoma with Hypercortisolism in a Patient Presenting with Hypokalemic Metabolic Alkalosis |
title_sort | diagnosis of adrenocortical carcinoma with hypercortisolism in a patient presenting with hypokalemic metabolic alkalosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529648/ https://www.ncbi.nlm.nih.gov/pubmed/36262492 http://dx.doi.org/10.55729/2000-9666.1108 |
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