Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats

Two heat treatments were carried out at below (Ti6Al4V(800)) and above (Ti6Al4V(1050)) the beta-phase transformation temperature (T(TRANSUS) = 980 °C), to study the effect of microstructural changes on osseointegration. The alloys were implanted in the femurs of hind legs of Wistar rats for 15, 30,...

Descripción completa

Detalles Bibliográficos
Autores principales: Chávez Díaz, Mercedes Paulina, Henche, Soledad Aguado, Yanchuck, Mónica Rubio, de Arriba, Celia Clemente, Sierra, Román Cabrera, Rincón, María Lorenza Escudero, Hallen, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Biocompatibility Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529715/
https://www.ncbi.nlm.nih.gov/pubmed/36190567
http://dx.doi.org/10.1007/s10856-022-06691-2
_version_ 1784801559513661440
author Chávez Díaz, Mercedes Paulina
Henche, Soledad Aguado
Yanchuck, Mónica Rubio
de Arriba, Celia Clemente
Sierra, Román Cabrera
Rincón, María Lorenza Escudero
Hallen, José M.
author_facet Chávez Díaz, Mercedes Paulina
Henche, Soledad Aguado
Yanchuck, Mónica Rubio
de Arriba, Celia Clemente
Sierra, Román Cabrera
Rincón, María Lorenza Escudero
Hallen, José M.
author_sort Chávez Díaz, Mercedes Paulina
collection PubMed
description Two heat treatments were carried out at below (Ti6Al4V(800)) and above (Ti6Al4V(1050)) the beta-phase transformation temperature (T(TRANSUS) = 980 °C), to study the effect of microstructural changes on osseointegration. The alloys were implanted in the femurs of hind legs of Wistar rats for 15, 30, and 60 days. Histology of the femur sections obtained for the first 15 days showed inflammatory tissue surrounding the implants and tissue contraction, which prevented osseointegration in early stages. After 30 days, trabecular bone, reduction of inflammatory tissue around the implants, and osseointegration were observed in Ti6Al4V as received and Ti6Al4V(1050) alloys, while osseointegration was detected for the three alloys after 60 days. These results were supported through morphometric studies based on the analysis of Bone Implant Contact (BIC), where there was a larger bone contact after 60 days for the Ti6Al4V(1050) alloy; indicating that microstructural features of the Ti6Al4V alloys influence their osseointegration, with the lamellar microstructure (Ti6Al4V(1050)), being the most responsive. [Figure: see text]
format Online
Article
Text
id pubmed-9529715
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-95297152022-10-05 Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats Chávez Díaz, Mercedes Paulina Henche, Soledad Aguado Yanchuck, Mónica Rubio de Arriba, Celia Clemente Sierra, Román Cabrera Rincón, María Lorenza Escudero Hallen, José M. J Mater Sci Mater Med Biocompatibility Studies Two heat treatments were carried out at below (Ti6Al4V(800)) and above (Ti6Al4V(1050)) the beta-phase transformation temperature (T(TRANSUS) = 980 °C), to study the effect of microstructural changes on osseointegration. The alloys were implanted in the femurs of hind legs of Wistar rats for 15, 30, and 60 days. Histology of the femur sections obtained for the first 15 days showed inflammatory tissue surrounding the implants and tissue contraction, which prevented osseointegration in early stages. After 30 days, trabecular bone, reduction of inflammatory tissue around the implants, and osseointegration were observed in Ti6Al4V as received and Ti6Al4V(1050) alloys, while osseointegration was detected for the three alloys after 60 days. These results were supported through morphometric studies based on the analysis of Bone Implant Contact (BIC), where there was a larger bone contact after 60 days for the Ti6Al4V(1050) alloy; indicating that microstructural features of the Ti6Al4V alloys influence their osseointegration, with the lamellar microstructure (Ti6Al4V(1050)), being the most responsive. [Figure: see text] Springer US 2022-10-03 2022 /pmc/articles/PMC9529715/ /pubmed/36190567 http://dx.doi.org/10.1007/s10856-022-06691-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biocompatibility Studies
Chávez Díaz, Mercedes Paulina
Henche, Soledad Aguado
Yanchuck, Mónica Rubio
de Arriba, Celia Clemente
Sierra, Román Cabrera
Rincón, María Lorenza Escudero
Hallen, José M.
Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats
title Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats
title_full Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats
title_fullStr Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats
title_full_unstemmed Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats
title_short Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats
title_sort implantation of heat treatment ti6al4v alloys in femoral bone of wistar rats
topic Biocompatibility Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529715/
https://www.ncbi.nlm.nih.gov/pubmed/36190567
http://dx.doi.org/10.1007/s10856-022-06691-2
work_keys_str_mv AT chavezdiazmercedespaulina implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats
AT henchesoledadaguado implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats
AT yanchuckmonicarubio implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats
AT dearribaceliaclemente implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats
AT sierraromancabrera implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats
AT rinconmarialorenzaescudero implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats
AT hallenjosem implantationofheattreatmentti6al4valloysinfemoralboneofwistarrats

Ejemplares similares