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Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer

In the treatment of colorectal cancer patients with distant metastases, the development of new anticancer agents has considerably prolonged progression-free survival. Such survival benefits attributed to chemotherapy have increased the relative significance of local therapy in patients with limited...

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Autores principales: Sanuki, Naoko, Takeda, Atsuya, Tsurugai, Yuichiro, Eriguchi, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529716/
https://www.ncbi.nlm.nih.gov/pubmed/35857212
http://dx.doi.org/10.1007/s11604-022-01307-9
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author Sanuki, Naoko
Takeda, Atsuya
Tsurugai, Yuichiro
Eriguchi, Takahisa
author_facet Sanuki, Naoko
Takeda, Atsuya
Tsurugai, Yuichiro
Eriguchi, Takahisa
author_sort Sanuki, Naoko
collection PubMed
description In the treatment of colorectal cancer patients with distant metastases, the development of new anticancer agents has considerably prolonged progression-free survival. Such survival benefits attributed to chemotherapy have increased the relative significance of local therapy in patients with limited metastases. The liver is recognized as the most common site of metastasis of colorectal cancer because of the intestinal mesenteric drainage to the portal veins. Hepatic resection of isolated liver metastases of colorectal cancer is the only option for a potential cure. However, hepatic metastases are resectable in only approximately 20% of the patients. For remaining patients with high-risk resectable liver metastases or those who are unfit for surgery, less invasive, local therapies including radiation therapy (stereotactic body radiation therapy, SBRT) may have a potential role in treatment. Although the local control rate of SBRT for colorectal liver metastases has room for improvement, its less-invasive nature and broad indications deserve consideration. Future research should include SBRT dose escalation or the selection of patients who benefit from local ablative therapies. SBRT may offer an alternative, non-invasive approach for the treatment of colorectal liver metastases in a multidisciplinary treatment strategy.
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spelling pubmed-95297162022-10-05 Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer Sanuki, Naoko Takeda, Atsuya Tsurugai, Yuichiro Eriguchi, Takahisa Jpn J Radiol Invited Review In the treatment of colorectal cancer patients with distant metastases, the development of new anticancer agents has considerably prolonged progression-free survival. Such survival benefits attributed to chemotherapy have increased the relative significance of local therapy in patients with limited metastases. The liver is recognized as the most common site of metastasis of colorectal cancer because of the intestinal mesenteric drainage to the portal veins. Hepatic resection of isolated liver metastases of colorectal cancer is the only option for a potential cure. However, hepatic metastases are resectable in only approximately 20% of the patients. For remaining patients with high-risk resectable liver metastases or those who are unfit for surgery, less invasive, local therapies including radiation therapy (stereotactic body radiation therapy, SBRT) may have a potential role in treatment. Although the local control rate of SBRT for colorectal liver metastases has room for improvement, its less-invasive nature and broad indications deserve consideration. Future research should include SBRT dose escalation or the selection of patients who benefit from local ablative therapies. SBRT may offer an alternative, non-invasive approach for the treatment of colorectal liver metastases in a multidisciplinary treatment strategy. Springer Nature Singapore 2022-07-20 2022 /pmc/articles/PMC9529716/ /pubmed/35857212 http://dx.doi.org/10.1007/s11604-022-01307-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Invited Review
Sanuki, Naoko
Takeda, Atsuya
Tsurugai, Yuichiro
Eriguchi, Takahisa
Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
title Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
title_full Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
title_fullStr Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
title_full_unstemmed Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
title_short Role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
title_sort role of stereotactic body radiotherapy in multidisciplinary management of liver metastases in patients with colorectal cancer
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529716/
https://www.ncbi.nlm.nih.gov/pubmed/35857212
http://dx.doi.org/10.1007/s11604-022-01307-9
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