Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma

The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acid...

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Autores principales: Kliebhan, Johannes, Besse, Andrej, Kampa‐Schittenhelm, Kerstin, Schittenhelm, Marcus, Driessen, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529752/
https://www.ncbi.nlm.nih.gov/pubmed/36225622
http://dx.doi.org/10.1002/ccr3.6296
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author Kliebhan, Johannes
Besse, Andrej
Kampa‐Schittenhelm, Kerstin
Schittenhelm, Marcus
Driessen, Christoph
author_facet Kliebhan, Johannes
Besse, Andrej
Kampa‐Schittenhelm, Kerstin
Schittenhelm, Marcus
Driessen, Christoph
author_sort Kliebhan, Johannes
collection PubMed
description The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.
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spelling pubmed-95297522022-10-11 Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma Kliebhan, Johannes Besse, Andrej Kampa‐Schittenhelm, Kerstin Schittenhelm, Marcus Driessen, Christoph Clin Case Rep Case Report The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease. John Wiley and Sons Inc. 2022-10-03 /pmc/articles/PMC9529752/ /pubmed/36225622 http://dx.doi.org/10.1002/ccr3.6296 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Kliebhan, Johannes
Besse, Andrej
Kampa‐Schittenhelm, Kerstin
Schittenhelm, Marcus
Driessen, Christoph
Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
title Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
title_full Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
title_fullStr Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
title_full_unstemmed Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
title_short Mutant TP53 driving the Warburg Effect in Mantle Cell lymphoma
title_sort mutant tp53 driving the warburg effect in mantle cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529752/
https://www.ncbi.nlm.nih.gov/pubmed/36225622
http://dx.doi.org/10.1002/ccr3.6296
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