The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury

Acute Lung Injury (ALI) due to inhaled pathogens causes high mortality. Underlying mechanisms are inadequately understood. Here, by optical imaging of live mouse lungs we show that a key mechanism is the viability of cytosolic Ca(2+) buffering by the mitochondrial Ca(2+) uniporter (MCU) in the lung’...

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Detalles Bibliográficos
Autores principales: Islam, Mohammad Naimul, Gusarova, Galina A., Das, Shonit R., Li, Li, Monma, Eiji, Anjaneyulu, Murari, Mthunzi, Liberty, Quadri, Sadiqa K., Owusu-Ansah, Edward, Bhattacharya, Sunita, Bhattacharya, Jahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529882/
https://www.ncbi.nlm.nih.gov/pubmed/36192486
http://dx.doi.org/10.1038/s41467-022-33543-y

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