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Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis
BACKGROUND: Patients newly diagnosed with cancer represent a population at highest risk for stroke. The objective of this systematic review and meta-analysis was to estimate the incidence of stroke in the first year following a new diagnosis of cancer. METHODS: We searched MEDLINE and EMBASE from Ja...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530058/ https://www.ncbi.nlm.nih.gov/pubmed/36203979 http://dx.doi.org/10.3389/fneur.2022.966190 |
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author | Lun, Ronda Roy, Danielle Carole Hao, Yu Deka, Rishi Huang, Wen-Kuan Navi, Babak B. Siegal, Deborah M. Ramsay, Tim Fergusson, Dean Shorr, Risa Dowlatshahi, Dar |
author_facet | Lun, Ronda Roy, Danielle Carole Hao, Yu Deka, Rishi Huang, Wen-Kuan Navi, Babak B. Siegal, Deborah M. Ramsay, Tim Fergusson, Dean Shorr, Risa Dowlatshahi, Dar |
author_sort | Lun, Ronda |
collection | PubMed |
description | BACKGROUND: Patients newly diagnosed with cancer represent a population at highest risk for stroke. The objective of this systematic review and meta-analysis was to estimate the incidence of stroke in the first year following a new diagnosis of cancer. METHODS: We searched MEDLINE and EMBASE from January 1980 to June 2021 for observational studies that enrolled adults with a new diagnosis of all cancers excluding non-melanoma skin cancer, and that reported the incidence of stroke at 1 year. PRISMA guidelines for meta-analyses were followed. Two reviewers independently extracted data and appraised risk of bias. We used the Dersimonian and Laird random effects method to pool cumulative incidences after logit transformation, and reported pooled proportions as percentages. Statistical heterogeneity was assessed using the I(2) statistic. RESULTS: A total of 12,083 studies were screened; 41 studies were included for analysis. Data from 2,552,121 subjects with cancer were analyzed. The cumulative incidence of total stroke at 1 year was 1.4% (95% CI 0.9–2.2%), while the pooled incidence of ischemic stroke was 1.3% (95% CI 1.0–1.8%) and 0.3% (95% CI 0.1–0.9%) for spontaneous intracerebral hemorrhage (ICH), with consistently high statistical heterogeneity (>99% I(2)). CONCLUSION: The estimated incidence of stroke during the first year after a new diagnosis of cancer is 1.4%, with a higher risk for ischemic stroke than ICH. Cancer patients should be educated on the risk of stroke at the time of diagnosis. Future studies should evaluate optimal primary prevention strategies in this high-risk group of patients. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/ucwy9/. |
format | Online Article Text |
id | pubmed-9530058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95300582022-10-05 Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis Lun, Ronda Roy, Danielle Carole Hao, Yu Deka, Rishi Huang, Wen-Kuan Navi, Babak B. Siegal, Deborah M. Ramsay, Tim Fergusson, Dean Shorr, Risa Dowlatshahi, Dar Front Neurol Neurology BACKGROUND: Patients newly diagnosed with cancer represent a population at highest risk for stroke. The objective of this systematic review and meta-analysis was to estimate the incidence of stroke in the first year following a new diagnosis of cancer. METHODS: We searched MEDLINE and EMBASE from January 1980 to June 2021 for observational studies that enrolled adults with a new diagnosis of all cancers excluding non-melanoma skin cancer, and that reported the incidence of stroke at 1 year. PRISMA guidelines for meta-analyses were followed. Two reviewers independently extracted data and appraised risk of bias. We used the Dersimonian and Laird random effects method to pool cumulative incidences after logit transformation, and reported pooled proportions as percentages. Statistical heterogeneity was assessed using the I(2) statistic. RESULTS: A total of 12,083 studies were screened; 41 studies were included for analysis. Data from 2,552,121 subjects with cancer were analyzed. The cumulative incidence of total stroke at 1 year was 1.4% (95% CI 0.9–2.2%), while the pooled incidence of ischemic stroke was 1.3% (95% CI 1.0–1.8%) and 0.3% (95% CI 0.1–0.9%) for spontaneous intracerebral hemorrhage (ICH), with consistently high statistical heterogeneity (>99% I(2)). CONCLUSION: The estimated incidence of stroke during the first year after a new diagnosis of cancer is 1.4%, with a higher risk for ischemic stroke than ICH. Cancer patients should be educated on the risk of stroke at the time of diagnosis. Future studies should evaluate optimal primary prevention strategies in this high-risk group of patients. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/ucwy9/. Frontiers Media S.A. 2022-09-20 /pmc/articles/PMC9530058/ /pubmed/36203979 http://dx.doi.org/10.3389/fneur.2022.966190 Text en Copyright © 2022 Lun, Roy, Hao, Deka, Huang, Navi, Siegal, Ramsay, Fergusson, Shorr and Dowlatshahi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Lun, Ronda Roy, Danielle Carole Hao, Yu Deka, Rishi Huang, Wen-Kuan Navi, Babak B. Siegal, Deborah M. Ramsay, Tim Fergusson, Dean Shorr, Risa Dowlatshahi, Dar Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis |
title | Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis |
title_full | Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis |
title_fullStr | Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis |
title_full_unstemmed | Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis |
title_short | Incidence of stroke in the first year after diagnosis of cancer—A systematic review and meta-analysis |
title_sort | incidence of stroke in the first year after diagnosis of cancer—a systematic review and meta-analysis |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9530058/ https://www.ncbi.nlm.nih.gov/pubmed/36203979 http://dx.doi.org/10.3389/fneur.2022.966190 |
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